Beneficial Impact of bFGF Antisense Therapy in a Rat Model of Pulmonary Fibrosis.

Objectives: This study aims to explore basic fibroblast growth factor (bFGF)'s role in the development of pulmonary fibrosis through applying bFGF antisense oligonucleotide therapy in a rat model of pulmonary fibrosis.

Methods: Thirty rats were randomly divided into five groups: bFGF sense-transfected, bFGF antisense-transfected, null vector-transfected, pulmonary fibrosis (PF), and control groups. Sense, antisense, null, and PF groups were administered bleomycin to induce pulmonary fibrosis.