A rational designed multi-epitope vaccine elicited robust protective efficacy against Klebsiella pneumoniae lung infection.

Background: The emergence of drug-resistant strains of Klebsiella pneumoniae (K. pneumoniae) has become a significant challenge in the field of infectious diseases, posing an urgent need for the development of highly protective vaccines against this pathogen.

Methods And Results: In this study, we identified three immunogenic extracellular loops based on the structure of five candidate antigens using sera from K.

Effect of spatial distortions in head-mounted displays on visually induced motion sickness.

Incomplete optical distortion correction in VR HMDs leads to spatial dynamic distortion, which is a potential cause of VIMS. A perception experiment is designed for the investigation with three spatial distortion levels, with the subjective SSQ, five-scale VIMS level rating, and objective postural instability adopted as the evaluation metrics. The results show that the factor of spatial distortion level has a significant effect on all metrics increments (p<0.

Self-position awareness based presence and interaction in virtual reality.

The awareness of self-position, which refers to the location of our cyclopean eye, is essential to the experience of being immersed and for interacting with a virtual environment. Currently, individual variability in the cyclopean eye location is not considered when presenting virtual reality (VR) content. The effect of the cyclopean eye shift was analyzed with theoretical and experimental methods, and it was found that human vision is sensitive to the visual direction offset caused by the cyclopean eye shift.