Publications by authors named "Zhenping Guo"

Article Synopsis
  • The greater wax moth, Galleria mellonella, is a significant pest for beehives, causing economic losses, but it's also useful for scientific research due to its role as a model organism.
  • The study established a Gmebony knockout strain using CRISPR/Cas9, resulting in noticeable pigmentation changes in the larvae and adults, with darkening colors observed in later instars.
  • The research confirmed the effectiveness of using CRISPR/Cas9 for genetic modifications in G. mellonella and highlighted the ebony gene as a potential reference for future studies on gene functions and pest management strategies.
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Objective: Recognition of auditory brainstem response (ABR) waveforms may be challenging, particularly for older individuals or those with hearing loss. This study aimed to investigate deep learning frameworks to improve the automatic recognition of ABR waveforms in participants with varying ages and hearing levels.

Study Design: The research used a descriptive study design to collect and analyze pure tone audiometry and ABR data from 100 participants.

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Background: Sudden sensorineural hearing loss (SSNHL) is a prevalent emergency in ear, nose, and throat practice. Previous studies have demonstrated that intratympanic steroid therapy (IST) can serve as a salvage treatment for SSNHL after the failure of systemic steroid therapy (SST).

Objective: This study aimed to analyze the efficacy of modified IST involving the insertion of a tympanic tube and gelfoam as a salvage treatment for patients with SSNHL, and to explore its associated factors.

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A growing body of research recently suggested the association between vestibular dysfunction and cognitive impairment. Meniere's disease (MD), a common clinical vestibular disorder, is usually accompanied by hearing loss and emotional stress, both of which may mediate the relationship between vestibule dysfunction and cognition. It is currently unknown whether the cognitive decline in MD patients could improve through treatment and how it relates to multiple clinical characteristics, particularly the severity of vertigo.

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Background: To investigate the effects of hypoxia degree and sleep duration on vestibular function in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients. We made further study of the low oxygen levels of OSAHS and hypoxic duration on the impact of vestibular function, and further studied the OSAHS the longest apnea time and Vestibular Evoked Myogenic Potential (VEMP) abnormal rate and the relationship between the vestibular function of canal paralysis (CP).

Methods: A total of 87 OSAHS patients and 47 healthy individuals were enrolled in this study.

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Oscillatory pressure sintering is a novel crystal refinement technology. The doping of different concentrations of ZrB under oscillatory sintering technology (9 Hz) is discussed here, focusing on its macroscopic mechanics and oxidation resistance. In particular, doping 2.

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Backgrounds: Previous studies reported inconsistent results regarding associations between apolipoprotein E (APOE) polymorphism and clinical outcomes after ischemic stroke (IS), intracerebral hemorrhage (ICH), or subarachnoid hemorrhage (SAH). Thus, the study was designed to make a systematic review and meta-analysis regarding the association between APOE polymorphism and clinical outcome after IS, ICH, and SAH.

Methods: To identify studies eligible for this meta-analysis, we searched for articles published before August 2021 in the databases (PubMed, Web of Science, and Google Scholar).

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Molybdenum silicon boron alloy is regarded as the next generation of superalloy that is expected to replace nickel-based superalloys. However, the high-temperature oxidation resistance of Mo-Si-B alloy has always been an issue worth studying. In this study, Mo-9Si-8B alloy was prepared via a plasma oscillatory pressure sintering process and pre-oxidized at 1300 °C while maintaining a certain balance of mechanical and oxidation properties.

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Molybdenum-based alloys fabricated via selective laser melting are considered to represent the next generation of high-temperature structural materials, but the additive manufacturing technology aiming at refractory alloys has not been explored extensively. Multi-field coupling simulation can be used as a practical tool to simulate a single track of molybdenum alloy printed via selective laser melting, observe the topography of the molten pool over time, and determine the effect of Marangoni flow on defect suppression. In this study, the t, t, and the competition mechanism of spreading/solidification time were considered, the dominant spreading time was calculated, and a reasonable process parameter window for fabricating molybdenum alloy was obtained.

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Objective: Because of their high metabolic activity and low-resting oxygen tension, the organs of the inner ear are vulnerable to hypoxia, a condition that occurs repetitively in obstructive sleep apnea-hypopnea syndrome (OSAHS). The present study aimed to investigate the inner ear function of patients with OSAHS.

Methods: A total of 58 patients with OSAHS (116 ears) and 20 adults without OSAHS were enrolled in the present study.

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Objective: To analyze the association between genetic polymorphisms of DNA repair genes of XPD (751 Lys/Gln), XPC (PAT)and susceptibility to laryngeal carcinoma. To explore the effect between DNA repair genes of XPD (751 Lys/Gln), XPC (PAT) and carcinogenesis of LSCC(laryngeal squamous cell carcinoma).

Method: A case-control study was conducted involving 233 LSCC patients and 102 healthy controls to investigate the association between polymorphisms of XPD(751 Lys/Gln), XPC (PAT) and LSCC.

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Objective: To explore the operative approach for nasosinus tumors involving the base of the anterior cranial fossa.

Method: Seven cases with defects, diameter less than 2 cm, on the skull base without damage of the duramater were not repaired. Other 7 cases with defects, diameter more than 2.

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