Publications by authors named "Zhenpeng He"
Article Synopsis
- Immune checkpoint blockade (ICB) therapy shows promise for treating advanced cancers, but its effectiveness is often limited due to low response rates.
- Researchers developed a nanoparticle called TPM1 that specifically targets and binds to PD-L1 on tumor cell surfaces, altering its structure to enhance PD-L1 aggregation.
- In tests with mice, TPM1 demonstrated prolonged retention in tumors and improved anti-cancer effects by activating CD8 T cells, suggesting it could boost the efficacy of ICB therapy.
MicroRNAs have been shown to play a critical role in lung inflammatory diseases. Here, we report that knocking out miR-144/451 in mice exacerbates lipopolysaccharide (LPS)-induced lung inflammation. The lung inflammation in mice was induced by intratracheal instillation of LPS.
View Article and Find Full Text PDFHuangkui Capsule Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Macrophage Activation by Suppressing Inflammation and Oxidative Stress in Mice.
Evid Based Complement Alternat Med
September 2021
Background: Huangkui capsule (HKC) comprises the total flavonoid extract of flowers of (L.) Medicus. This study aimed to explore the effects of HKC on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice and LPS-stimulated RAW 264.
View Article and Find Full Text PDFTectochrysin, a flavonoid compound, can be isolated from propolis, Alpinia oxyphylla Miq, and Lychnophora markgravii. This study evaluated the efficacy of tectochrysin in the treatment of shrimp tropomyosin (ST)-induced mouse asthma. Mice were sensitized with intraperitoneal (i.
View Article and Find Full Text PDFAllergic asthma remains an important worldwide health issue. Animal models are valuable for understanding the pathophysiological mechanisms of asthma and the development of effective therapeutics. This study aims to develop an alternative murine model induced by shrimp tropomyosin (ST) instead of ovalbumin (OVA).
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