A Kinetically Stabilized Dianthraceno[2,3-a:3',2'-h]-s-Indacene: Stable Kekulé Diradical Polycyclic Hydrocarbon with Triplet Ground State.

High-spin polycyclic hydrocarbons (PHs) hold significant potential in organic spintronics and organic magnets. However, their synthesis is very challenging due to their extremely high reactivity. Herein, we report the successful synthesis and isolation of a kinetically blocked derivative (1) of dianthraceno[2,3-a : 3',2'-h]-s-indacene, which represents a rare persistent triplet diradical of a Kekulé PH.

Helical polycyclic hydrocarbons with open-shell singlet ground states and ambipolar redox behaviors.

Organic π-conjugated polycyclic hydrocarbons (PHs) with an open-shell diradical character are attracting increasing interest due to their promising applications in organic electronics and spintronics. However, most of the open-shell PHs synthesized thus far are based on planar π-conjugated molecules. Herein, we report the synthesis and characterization of two new quinodimethane-embedded expanded helicenes H1 and H2.

Synthetic Investigation toward QS-21 Analogues.

With glycosyl -alkynylbenzotes as donors, a highly efficient protocol to construct the challenging glycosidic linkages at C3-OH of C23-oxo oleanane triterpenoids is disclosed, on the basis of which different strategies for the highly efficient synthesis of QS-21 analogues with the west-wing trisaccharide of QS-21 have been established.

Circulating miR-130b- and miR-21-based diagnostic markers and therapeutic targets for hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) is one of the histological types of primary liver cancer with high recurrence and mortality in the world. The purpose of this study was to explore the diagnostic and therapeutic value for HCC patients.

Methods: In this study, we investigated the circulating miR-130b-5p (miR-130b) and miR-21-5p (miR-21) expression levels in patients with HCC and their association with clinical parameters.