Publications by authors named "Zhenming Tang"
Article Synopsis
- Small non-coding RNAs, particularly mitochondria-derived small RNA (mtRNA), show promise as diagnostic biomarkers for lung cancer, but studies focusing on mtRNA in humans are limited.
- Current normalization methods for detecting differentially expressed small non-coding RNAs are inconsistent, highlighting the need for more reliable approaches.
- A new ratio-based prediction model using mtRNA from blood samples achieved high accuracy in distinguishing lung cancer patients from controls, suggesting its potential for enhancing blood-based lung cancer screening and improving diagnosis in clinical settings.
mtTB: A Web-Based R/Shiny App for Pulmonary Tuberculosis Screening.
Front Cell Infect Microbiol
April 2022
Pulmonary tuberculosis caused by Mycobacterium tuberculosis remains a global issue. However, the diagnosis of active pulmonary tuberculosis (TB) remains a challenge in the clinic. Small non-coding RNAs are potential diagnostic biomarkers for pulmonary tuberculosis.
View Article and Find Full Text PDFAim: Carbapenem-resistant - (CR-Kp-) mediated infections represent a challenge for clinical practitioners due to their expanding prevalence in hospital environments and antibiotic resistance. However, few studies have shown metabolic changes of carbapenem-resistant and CR-Kp-negative patients, and relevant studies are urgently needed.
Methods: In this study, we comprehensively profile the metabolites of 20 CR-Kp-positive and 18 CR-Kp-negative patients in plasma by using 2D gas chromatography-time-of-flight mass spectrometry (GC×GC-TOFMS).
Background: Therapeutic outcomes of osteosarcoma treatment have not significantly improved in several decades. Therefore, strong prognostic biomarkers are urgently needed.
Methods: We first extracted the tRNA-derived small RNA (tsRNA) expression profiles of osteosarcoma from the GEO database.
Background: Identifying malignant pulmonary nodules and detecting early-stage lung cancer (LC) could reduce mortality. This study investigated the clinical value of a seven-autoantibody (7-AAB) panel in combination with the Mayo model for the early detection of LC and distinguishing benign from malignant pulmonary nodules (MPNs).
Methods: The concentrations of the elements of a 7-AAB panel were quantitated by enzyme-linked immunosorbent assay (ELISA) in 806 participants.
Background: Lung cancer (LC) is top-ranked in cancer incidence and is the leading cause of cancer death globally. Combining serum biomarkers can improve the accuracy of LC diagnosis. The identification of the best potential combination of traditional tumor markers is essential for LC diagnosis.
View Article and Find Full Text PDFLong non-coding RNA TGFB2-antisense RNA1 (TGFB2-AS1) has been reported could regulate tumorigenesis. However, the roles of TGFB2-AS1 in lung adenocarcinoma (LUAD) remain largely unknown. In this work, we aimed to explore the expression levels of TGFB2-AS1 and mechanisms in regulating LUAD progression.
View Article and Find Full Text PDFObjective: We performed a comprehensive review and meta-analysis to evaluate the diagnostic values of serum single and multiplex tumor-associated autoantibodies (TAAbs) in patients with lung cancer (LC).
Methods: We searched the MEDLINE and EMBASE databases for relevant studies investigating serum TAAbs for the diagnosis of LC. The primary outcomes included sensitivity, specificity and accuracy of the test.
Background: Nebulized magnesium sulfate (MgSO) has been used to treat asthma, but the efficacy remains controversial. We aimed to comprehensively review the efficacy of nebulized MgSO in treating adult patients with asthma.
Methods: PubMed, Embase, and Cochrane Library were searched for relevant studies published up to July 18, 2016.
Objective: Pleural lavage cytology (PLC) is considered as a possible tool for assessing prognosis of lung cancer patients. We aimed to comprehensively review the prognosis value of PLC in patients undergoing surgical resection.
Methods: We searched 4 electronic databases for relevant studies comparing positive PLC and negative PLC.