WDR5 promotes the proliferation of lung adenocarcinoma by inducing SOX9 expression.

WDR5 is a coactivator of transcription factor which promotes the progression of several cancer types, but its function in lung adenocarcinoma (AC) is unknown. We detected WDR5 expression in lung AC with quantitative real-time polymerase chain reaction and immunohistochemistry. WDR5 was significantly overexpressed in ACs compared with normal lung tissues.

Dynamin 2 Is Correlated with Recurrence and Poor Prognosis of Papillary Thyroid Cancer.

BACKGROUND Papillary thyroid cancer (PTC) is the most common histological type of thyroid cancer. Most PTC patients have favorable outcomes, but 10% of patients still have distant metastases at presentation or during follow-up. Dynamin 2 (DNM2) is the only DNM ubiquitously expressed in human tissues, but its expression and clinical significance in PTC is still unknown.