Spatiotemporal variations and tradeoff-synergy relations of ecosystem services under ecological water replenishment in Baiyangdian Lake, North China.

Understanding dynamic variations of ecosystem services (ESs) and their tradeoff-synergy relations under ecological water replenishment (EWR) is conducive to the formulation of effective eco-environmental management strategies. In this study, spatiotemporal variations of three leading ESs, namely habitat quality, carbon storage and water yield services influenced by EWR in Baiyangdian Lake, North China from 1991 to 2019, were investigated using the "Integrated Valuation of Ecosystem Services and Tradeoffs" (InVEST) model, and their tradeoff-synergy relations were quantitatively assessed with correlation analysis methods. Our results showed that habitat quality had continuously declined, whereas it got a steady improvement after the year of 2015.

A new framework combining hydrological connectivity metrics and morphological spatial pattern analysis for the hydrological connectivity evaluation of wetlands.

The quantitative evaluation of wetland hydrological connectivity is essential to the hydrological connectivity restoration-oriented ecological conservation and environmental management of wetlands. We proposed a framework to evaluate wetland hydrological connectivity with a combination of hydrological connectivity metrics and morphological spatial pattern analysis and recognized potential sites and links that had been generally overlooked in previous studies. Variations in hydrological connectivity revealed a decreasing trend followed by a gradual recovery from the critical time node of 2005 in Baiyangdian Lake.

Outcomes of closure of doubly committed subarterial ventricular septal defects in adults.

Background: Outcome data of doubly committed subarterial ventricular septal defect closure in adults are limited.

Methods: A review was made of the inpatients >18 years of age who underwent doubly committed subarterial ventricular septal defect closure between June 2010 and June 2017.

Results: The patients were categorised into two groups: The valve intervention group consisted of 31 patients who underwent aortic valvuloplasty, aortic valve replacement, or repair of sinus Valsalva aneurysm in addition to doubly committed subarterial ventricular septal defect closure; non-valvular intervention group comprised 58 patients who underwent only doubly committed subarterial ventricular septal defect closure.

Long-term outcomes after conventional surgical repair versus perventricular device occlusion for doubly committed subarterial ventricular septal defects: a propensity score matched study.

Objectives: This study aimed to investigate the long-term outcomes of perventricular device occlusion and surgical repair for doubly committed subarterial ventricular septal defect using propensity score matched analysis because previous comparative studies were limited by differences in the baseline characteristics.

Methods: We reviewed inpatients with isolated doubly committed subarterial ventricular septal defect aged <18 years who underwent surgical repair or device occlusion between January 2011 and December 2017. Propensity score matching was used to assemble a cohort of patients with similar baseline characteristics.

N,N-dimethylsphingosine attenuates myocardial ischemia-reperfusion injury by recruiting regulatory T cells through PI3K/Akt pathway in mice.

N,N-dimethylsphingosine (DMS) has been documented to be in vitro protective against myocardial ischemia-reperfusion injury (IRI) and can recruit CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), which may participate in the cardioprotection. We hypothesized that when in vivo applied after a myocardial ischemia, DMS may be cardioprotective by recruiting Tregs. Myocardial IRI was induced in C57BL/6 mice by occluding the left main coronary arteries followed by relaxation, and DMS (0.

Orally available and efficacious α4β1/α4β7 integrin inhibitors.

A series of potent α4β1/α4β7 integrin inhibitors is reported, including an inhibitor 12d with remarkable oral exposure and efficacy in rat models of rheumatoid arthritis and Crohn's disease.

Arylsulfonamide pyrimidines as VLA-4 antagonists.

A series of (S)-2-(2-(diethylamino)-5-(N-alkyl-N-sulfonamido)pyrimidin-4-ylamino)-3-(4-(carbamoyloxy)phenyl)propanoic acid is discovered as orally available VLA-4 antagonists. Representative compounds 11b and 11p showed efficacy in multiple in vivo animal models. The in vitro selectivity of 11p is also described.