Publications by authors named "Zhenlv Lin"
Article Synopsis
- * The study shows that Miltirone can reduce the viability of CRC cells and trigger pyroptotic cell death by cleaving gasdermin E (GSDME), an important protein in this process.
- * Inhibition of GSDME or caspase 3 can diminish the cell death caused by Miltirone, suggesting that Miltirone might be a promising new treatment for CRC by promoting pyroptosis.
Background: The purpose of this study was to compare the outcomes of vacuum sealing drainage (VSD) and conventional incision and drainage (I&D) for treating acute suppurative mastitis.
Methods: Hospital medical records were searched for patients 20-50 years of age who were diagnosed with acute suppurative mastitis from January 2014 to December 2018, and treated with traditional I&D or VSD. Patients were divided into those treated with VSD and I&D, and outcomes including pain, healing time, length of hospital stay, and length of antibiotic course were compared between the groups.
Background: COVID-19 pandemic has forced physicians to quickly determine the patient's condition and choose treatment strategies. This study aimed to build and validate a simple tool that can quickly predict the deterioration and survival of COVID-19 patients.
Methods: A total of 351 COVID-19 patients admitted to the Third People's Hospital of Yichang between 9 January to 25 March 2020 were retrospectively analyzed.
Objective: The aim of the study is to determine the role of nuclear receptor coactivator 2 in cell proliferation and invasion ability of gastric cancer cells and to explore its possible mechanisms.
Methods: Immunohistochemical staining was used to determine gene expression in gastric cancer. Western blotting was used to detect Wnt signal pathways-related protein expression.
Article Synopsis
- * The study focused on creating nanoparticles that combine magnetic properties and a targeting peptide to enhance drug delivery specifically to liver tumors in mice.
- * Results showed that these nanoparticles not only gathered in the liver using magnetic forces but also penetrated tumor cells effectively, making them a promising system for targeted liver cancer therapy using paclitaxel.
The aberrant expression of tumor suppressor Smad4 often occurs in colorectal cancer (CRC), and this phenomenon is believed to be associated with drug resistance. The present study aimed to investigate the effects of Smad4 on the sensitivity of CRC cells to cetuximab, and the possible mechanism underlying such an effect. A total of 629 colorectal adenocarcinoma cases were downloaded from The Cancer Genome Atlas (TCGA) database, and a Smad4 mutation rate of ~21% was demonstrated among the cases.
View Article and Find Full Text PDFAim: To investigate the effectiveness of over-the-scope-clip (OTSC)-based endoscopic closure in patients with perforated peptic ulcer (PPU).
Methods: One hundred six patients diagnosed with PPU were treated with either OTSC (n = 26) or conservative treatments (n = 80), respectively. The outcome assessments included technical success rate, clinical success rate, post-treatment complications after 1 month, mortality rate, time to resume oral feeding, length of hospital stay, and the administration of antibiotics.
BACKGROUND MicroRNAs have been reported to play significant roles in pathogenesis of colorectal cancer (CRC). In the present study, we aimed to investigate the functional role of microRNA-455-3p (miR-455-3p) in CRC, as well as its underlying mechanisms. MATERIAL AND METHODS Human colon cancer cell line HCT116 cells were transfected with miR-455-3p mimics, inhibitors, or controls.
View Article and Find Full Text PDFArticle Synopsis
- Aberrant T cell activation contributes to intestinal inflammation, particularly in conditions like ulcerative colitis (UC), and the study investigates the effectiveness of combining specific immunotherapy (SIT) with the probiotic C. butyricum (Cb) in alleviating UC symptoms.
- Conducted as a randomized, double-blind clinical trial, the study involved 80 patients with relapsing-remitting UC and high IgE levels, who were divided into four treatment groups: SIT, Cb, both, or a placebo, over one year.
- Results indicated that the combination of SIT and Cb led to significant improvements in UC symptoms, lower reliance on UC medications, and a reversal of
Article Synopsis
- This study aims to create a rat model of gastric precancerous lesions and investigate how mesenchymal stem cells (BMMSCs) affect these lesions.
- The model was developed using a chemical agent, and researchers observed how BMMSCs migrated and their impact on factors associated with gastric precancer, like VEGF, IL-10, and IFN-γ.
- Results indicated that BMMSCs could differentiate into relevant cell types and significantly alter the expression of growth and inflammatory factors, suggesting a potential to mitigate gastric precancerous conditions.*