12-HETE/GPR31 induces endothelial dysfunction in diabetic retinopathy.

12-hydroxyeicosatetraenoic acid (12-HETE), a major metabolite of arachidonic acid, is converted by 12/15-lipoxygenase and implicated in diabetic retinopathy (DR). Our previous study demonstrated a positive correlation between 12-HETE and the prevalence of DR. However, reasons for the increased production of 12-HETE are unclear, and the underlying mechanisms through which 12-HETE promotes DR are unknown.

In-situ generated NiCoO/CoP polyhedron with rich oxygen vacancies interpenetrating by P-doped carbon nanotubes for high performance supercapacitors.

Supercapacitor with high storage capacity and small volumes are the development trends of miniaturization and portable energy storage systems. Herein, we design a novel self-supporting P-doped carbon nanotube (P-CNT) intercalating NiCoO/CoP core-shell polyhedron film. P-CNT is an ideal substrate with high electrical conductivity and interconnected porous architecture, which can enable the electrons transport to an external circuit from the electroactive component.

Carbon nanotubes interpenetrating MOFs-derived Co-Ni-S composite spheres with interconnected architecture for high performance hybrid supercapacitor.

Recently, carbon nanotubes (CNT)-based interconnected architectures exhibit promising prospects in supercapacitors due to their flexibility and high electrical conductivity. Herein, a three-dimensional (3D) interconnected network structure combined with conductive carbon nanotubes interpenetrating MOFs-derived Co-Ni-S composite spheres (Co-Ni-S/CNTs) was synthesized. Such 3D interconnected architecture significantly leads to a favorable electronic structure, fast charge-transfer capacity, and more pseudocapacitive.

High-performance supercapacitor based on highly active P-doped one-dimension/two-dimension hierarchical NiCoO/NiMoO for efficient energy storage.

Multi-dimensional metal oxides have become a promising alternative electrode material for supercapacitors due to their inherent large surface area. Herein, P-doped NiCoO/NiMoO multi-dimensional nanostructures are synthesized on carbon clothes (CC) with a continuous multistep strategy. Especially, P has the best synergistic effect with transition metals, such as optimal deprotonation energy and OH adsorption energy, which can further enhance electrochemical reaction activity.

Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites.

The heterochromatin environment plays a central role in silencing genes associated with the malaria parasite's development, survival in the host, and transmission to the mosquito vector. However, the underlying mechanism regulating the dynamic chromatin structure is not understood yet. Here, we have uncovered that Rrp6, an orthologue of eukaryotic RNA exosome-associated RNase, controls the silencing of heterochromatic genes.

Pore Space Partition within a Metal-Organic Framework for Highly Efficient CH/CO Separation.

The pore space partition (PSP) approach has been employed to realize a novel porous MOF (FJU-90) with dual functionalities for the challenging CH/CO separation under ambient conditions. By virtue of a triangular ligand (Tripp = 2,4,6-tris(4-pyridyl)pyridine), the cylindrical channels in the original FJU-88 have been partitioned into uniformly interconnected pore cavities, leading to the dramatically reduced pore apertures from 12.0 × 9.

Additive-Induced Supramolecular Isomerism and Enhancement of Robustness in Co(II)-Based MOFs for Efficiently Trapping Acetylene from Acetylene-Containing Mixtures.

Although supramolecular isomerism in metal-organic frameworks (MOFs) would offer a favorable platform for in-depth exploring their structure-property relationship, the design and synthesis of the isomers are still rather a challenging aspect of crystal engineering. Here, a pair of supramolecular isomers of Co(II)-based MOFs (FJU-88 and FJU-89) can be directionally fabricated by rational tuning the additives. In spite of the fact that the isomers have the similar Co secondary building units and organic linkers, they adopt distinct networks with acs and snw topologies, respectively, which derive from the conformational flexibility of the organic ligands.