Publications by authors named "Zhenkun He"

Under the initiative of the United Nations Sustainable Development Goals (SDGs), utilization of clean energy for metallurgy has emerged as a new trend in recent years. Precious metal ions with low chemical reactivity have been readily photoreduced, while active metal such as copper has been rarely reported. In this work, photocatalytic reduction of Cu(II) ions was investigated utilizing TiO nanoparticles as catalyst.

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The detrimental effects of inflammation on cardiovascular health have received a lot of attention. However, the relationship between heart failure (HF) and the systemic immune-inflammation index (SII) has not been demonstrated. The authors sought to learn more about the relationship between HF and SII in US adults.

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This paper reports a 49-year-old male patient with a long-term smoking history who developed renal insufficiency and proteinuria in the range of nephropathy without diabetes. Renal biopsy showed nodular glomerulosclerosis with vitreous degeneration of arterioles and moderate and severe proliferation of glomerular mesangial cells and matrix. The patient was diagnosed with idiopathic nodular glomerulosclerosis.

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Article Synopsis
  • Formaldehyde (HCHO) is a harmful substance found in various products, and the study introduces a new sensitive sensor using Pd nanoclusters integrated into a mesoporous TiO structure to detect it.
  • The sensor benefits from a large surface area and enhanced adsorption capacity, resulting in quick response/recovery times and excellent sensitivity, detecting HCHO at very low concentrations (4.51 ppb) under UV light.
  • The design includes a wearable gas sensing band for real-time HCHO detection in cigarette smoke, showing potential for environmental monitoring and smart sensing applications.
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In all their applications, gas sensors should satisfy several requirements, including low cost, reduced energy consumption, fast response/recovery, high sensitivity, and reliability in a broad humidity range. Unfortunately, the fast response/recovery and sensing reliability under high humidity conditions are often still missing, especially those working at room temperature. In this study, a humidity-resistant gas sensor with an ultrafast response/recovery rate was designed by integrating a defect-rich semiconducting sensing interface and a self-assembled monolayer (SAM) with controllable wettability.

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In this study, we developed a gas sensing platform that can sensitively and specifically detect trace HS in a high-humidity atmosphere at RT. Upon integrating a carbon nitride (CN) nanofilm and molybdenum dioxide (MoO) nanosheets onto nanojungle-like TiO nanotube arrays (TiNTs), the fabricated chemiresistor showed rapid response (38 s)/recovery (58 s) abilities and remarkable detection sensitivity for HS at concentrations down to 2 ppb, with an estimated detection limit of 1.13 ppb at RT and room-environmental light (REL).

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Formaldehyde is ubiquitously found in the environment, meaning that real-time monitoring of formaldehyde, particularly indoors, can have a significant impact on human health. However, the performance of commercially available interdigital electrode-based sensors is a compromise between active material loading and steric hindrance. In this work, a spaced TiO nanotube array (NTA) was exploited as a scaffold and electron collector in a formaldehyde sensor for the first time.

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Article Synopsis
  • Enzyme-mimicking nanoparticles are important for various applications, and understanding their performance can enhance biological uses like biosensing and energy conversion.
  • The study presents a novel electrochemical method for monitoring glucose oxidase-like activity of single nanoparticles in real-time using specially designed electrodes made from doped polyaniline on titanium nanotubes.
  • The research connects the activity of nanoparticles to changes in their environment, using glucose reactions to explore how their catalytic functions can be characterized at the single-nanoparticle level.
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As a biomarker of periodontitis, sensitive and timely monitoring of hydrogen sulfide (HS) in exhaled breath at room temperature (RT) is important for the early intervention of oral diseases. However, the required high operation temperature to achieve high sensitivity is still a technical challenge for directly monitoring exhaled breath. In this study, by integrating metal-organic frameworks (MOFs) into self-aligned TiO nanotube arrays (NTs), a chemiresistor gas sensor with outstanding sensitivity and selectivity was constructed for the detection of HS at RT.

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Circular RNAs act as vital regulators in diverse diseases. However, the investigation of circular RNAs in sepsis-engendered acute kidney injury remains dismal. We aimed to explore the effects of circular RNA protein kinase C iota (circ-PRKCI) in lipopolysaccharide (LPS)-mediated HK2 cell injury.

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MicroRNAs (miRNAs) have already been documented to function in diabetic nephropathy (DN), yet little research has focused on the role of miR-98 in this disease. Here, we discuss the mechanism of miR-98 on the renal fibrosis in DN. Recombinant adeno-associated virus carrying miR-98 inhibitor or Nedd4L overexpression plasmid was injected into DN modeled rats to explore their roles in DN.

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Taccalonolide A has been reported to have anti-tumour efficiency. However, the underlying mechanism for taccalonolides A therapy of hepatocellular carcinoma (HCC) is still obscure. Cell viability was evaluated by cell counting kit-8 (CCK-8) assay.

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BACKGROUND Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Mesenchymal stem cells (MSCs) treatment has been proved to be effective in DN models by protecting renal function and preventing fibrosis. However, the underlying mechanism is unclear.

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Purpose: Hepatitis C virus (HCV) infection is a major cause of liver disease. Several miRNAs have been found to be associated with HCV infection. This study aimed to investigate the functional roles and possible molecular mechanisms of miR-215 in HCV replication.

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Background: Hepatitis B virus (HBV) chronic infection is a health problem in the worldwide, with a underlying higher risk of liver cirrhosis and hepaticocellular carcinoma. A number of studies indicate that microRNAs (miRNAs) play vital roles in HBV replication. This study was designed to explore the potential molecular mechanism of miR-200c in HBV replication.

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Background: This study aims to observe the outcome and safety of umbilical cord-mesenchymal stem cell (UC-MSC) treatment for continuous ambulatory peritoneal dialysis (CAPD) patients.

Methods: A total of 24 CAPD patients, who underwent UC-MSC treatment from June 2011 to December 2012, were selected for this study. These patients were followed up until June 2015.

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Objectives: Interactions between the host and gut microbial community contribute to the pathogenesis of Crohn's disease (CD). In this study, we aimed to detect lipopolysaccharide (LPS) and 1,3-β-D-glucan (BG) in the sera of CD patients and clarify the potential role in the diagnosis and therapeutic approaches.

Materials And Methods: Serum samples were collected from 46 patients with active CD (A-CD), 22 CD patients at remission stage (R-CD), and 20 healthy controls, and the levels of LPS, BG, and TNF in sera were determined by ELISA.

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