Publications by authors named "Zhenkui Wang"
A Multi-Contrast Translation-Based Registration Approach for Distortion Correction in DTI.
Annu Int Conf IEEE Eng Med Biol Soc
July 2024
Correcting eddy currents and motion artifacts is crucial in Diffusion Tensor Imaging (DTI) preprocessing, traditionally managed through affine registration to an undistorted reference. However, the contrast variation across diffusion-weighted images complicates direct registration. To surmount this challenge, our study introduces a translation-based registration approach, utilizing 312 DTI datasets from the Human Connectome Project (HCP), including both b=0 and b=2000 volumes.
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- T2-weighted 2D fast spin echo is the standard for pelvic MR imaging but suffers from motion artifacts due to peristalsis, resulting in challenges and the need for patient discomfort because of preparation methods.
- A new dynamic imaging approach is introduced that allows imaging without any prior patient preparation, using rapid data collection and advanced reconstruction techniques to minimize motion issues.
- Experimental results show that this innovative method significantly reduces motion artifacts and improves the clarity of structural details compared to traditional static imaging techniques.
Article Synopsis
- Cardiovascular diseases are highly prevalent in advanced chronic kidney disease patients, often leading to cardiac dysfunction due to issues like hypertrophy and fibrosis, highlighting the need for new therapies aimed at preserving heart function.
- The study aimed to identify potential treatments for cardiorenal syndrome type 4 (CRS) through a combination of molecular phenotyping and various experimentation methods, including gene expression analysis and different staining techniques.
- The findings revealed that Lobetyolin (LBT) improved cardiac dysfunction in animal models and that its mechanism involves the suppression of Osteopontin (OPN) through JNK signaling, indicating a potential therapeutic pathway for CRS.
Article Synopsis
- Cardiorenal syndrome type 4 (CRS type 4) poses significant health risks globally, and Zhen-Wu decoction has been traditionally used in East Asia for treating related cardiovascular and kidney diseases, though its mechanisms are not well-studied.
- This study aimed to explore how Zhen-Wu decoction can affect uremic cardiomyopathy, providing insights for potential clinical treatments for CRS type 4.
- Results showed that Zhen-Wu decoction improved heart function in mice and suggested that the Nrf2 signaling pathway is crucial for its protective effects against oxidative stress and inflammation in kidney-related conditions.
Invariant natural killer T (iNKT) cells are a unique subset of T cells that have been implicated in inflammation, atopy, autoimmunity, infections, and cancer. Although iNKT cells have been extensively studied over the past decade, its role in the pathogenesis of ischemic brain injury is still largely unknown. In our study, we determined whether iNKT cells infiltration occur in a mouse model of permanent cerebral ischemia.
View Article and Find Full Text PDFObjective: To study the expression of Cx32 and Cx43 in medically intractable temporal lobe epilepsy in human and investigate the pathogenic relationship between gap junctions and seizures.
Methods: The expression of Cx32 and Cx43 was detected by Western blot and immunohistochemistry in 14 consecutive samples of hippocampus from epileptic patients undergoing an amygdalohippocampectomy for the treatment of intractable seizures. During postmortem dissection, 8 samples of hippocampus in nonepileptic patients dying of other diseases were taken as control group.