Tailored Metal-Organic Framework-Based Nanozymes for Enhanced Enzyme-Like Catalysis.

The global crisis of bacterial infections is exacerbated by the escalating threat of microbial antibiotic resistance. Nanozymes promise to provide ingenious solutions. Here, we reported a homogeneous catalytic structure of Pt nanoclusters with finely tuned metal-organic framework (ZIF-8) channel structures for the treatment of infected wounds.

Reinforced Magnetic-Responsive Electro-Ionic Artificial Muscles by 3D Laser-Induced Graphene Nano-Heterostructures.

Efficient ion transport and enriched responsive modals via modulating electrochemical properties of conductivity and capacitance are essential for soft electro-ionic actuators. However, cost-effective and straightforward approaches to achieve expedited fabrication of active electrode materials capable of multimodal-responsiveness remain limited. Herein, this work reports the one-step ultrafast laser direct patterning method, to readily synthesize electro- and magneto-active electrode material, derived from the unique cobalt-phosphorus co-doped core-shell heterostructures within 3D graphene frameworks, for fulfilling the dual-mode responsive electro-ionic actuators.

D-Band-Center-Engineered Platinum-Based Nanozyme for Personalized Pharmacovigilance.

A high-efficiency PtZnCd nanozyme was screened with density functional theory (DFT) and unique d-orbital coupling features for sensitive enrichment and real-time analysis of CO-releasing molecule-3 (CORM-3). Multicatalytic sites in the nanozyme showed a high reactivity of up to 72.89 min for peroxidase (POD)-like reaction, which was 2.

Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota.

Curcumin (CUR) is a natural polyphenol that holds promise for treating ulcerative colitis (UC), yet oral administration of CUR exhibits limited bioavailability and existing formulations for oral delivery of CUR often suffer from unsatisfactory loading capacity. This study presents hydroxyethyl starch-curcumin microspheres (HC-MSs) with excellent CUR loading capacity (54.52 %), and the HC-MSs can further encapsulate anti-inflammatory drugs dexamethasone (DEX) to obtain a combination formulation (DHC-MSs) with high DEX loading capacity (19.

Colon-Targeted Oral Delivery of Hydroxyethyl Starch-Curcumin Microcapsules Loaded with Multiple Drugs Alleviates DSS-Induced Ulcerative Colitis in Mice.

Combination therapy through colon-targeted oral delivery of multiple drugs presents a promising approach for effectively treating ulcerative colitis (UC). However, the codelivery of drugs with diverse physicochemical properties in a single formulation remains a formidable challenge. Here, microcapsules are designed based on hydroxyethyl starch-curcumin (HES─CUR) conjugates to enable the simultaneous delivery of hydrophobic dexamethasone acetate (DA) and hydrophilic cefazolin sodium (CS), yielding multiple drug-loaded microcapsules (CS/DA-loaded HES─CUR microcapsules, CDHC-MCs) tailored for colon-targeted therapy of UC.

High-Linearity Flexible Pressure Sensor Based on the Gaussian-Curve-Shaped Microstructure for Human Physiological Signal Monitoring.

Flexible pressure sensors with high-performance show broad application prospects in health monitoring, wearable electronic devices, intelligent robot sensing, and other fields. Although flexible pressure sensors have made significant progress in sensitivity and detection range, most of them still exhibit strong nonlinearity, which leads to significant troubles in signal acquisition and thus limits their popularity in practical applications. It remains a serious challenge for the flexible pressure sensor to achieve high linearity while maintaining high sensitivity.

Self-Patterning of Highly Stretchable and Electrically Conductive Liquid Metal Conductors by Direct-Write Super-Hydrophilic Laser-Induced Graphene and Electroless Copper Plating.

Stretchable electrodes are desirable in flexible electronics for the transmission and acquisition of electrical signals, but their fabrication process remains challenging. Herein, we report an approach based on patterned liquid metals (LMs) as stretchable electrodes using a super-hydrophilic laser-induced graphene (SHL-LIG) process with electroless plating copper on a polyimide (PI) film. The LMs/SHL-LIG structures are then transferred from the PI film to an Ecoflex substrate as stretchable electrodes with an ultralow sheet resistance of 3.

A flexible pressure sensor with highly customizable sensitivity and linearity via positive design of microhierarchical structures with a hyperelastic model.

The tactile pressure sensor is of great significance in flexible electronics, but sensitivity customization over the required working range with high linearity still remains a critical challenge. Despite numerous efforts to achieve high sensitivity and a wide working range, most sensitive microstructures tend to be obtained only by inverting naturally existing templates without rational design based on fundamental contact principles or models for piezoresistive pressure sensors. Here, a positive design strategy with a hyperelastic model and a Hertzian contact model for comparison was proposed to develop a flexible pressure sensor with highly customizable linear sensitivity and linearity, in which the microstructure distribution was precalculated according to the desired requirement prior to fabrication.

A flexible tactile sensor that uses polyimide/graphene oxide nanofiber as dielectric membrane for vertical and lateral force detection.

Flexible force sensors are of great interest in the fields of healthcare, physiological signals, and aircraft smart skin applications because of their compatibility with curved surfaces. However, the simultaneous detection of multidirectional forces remains an engineering challenge, despite the great progress made in recent years. Herein, we present the development of a flexible capacitive force sensor capable of efficiently distinguishing normal and sliding shear forces.

Design, fabrication and application of magnetically actuated micro/nanorobots: a review.

Magnetically actuated micro/nanorobots are typical micro- and nanoscale artificial devices with favorable attributes of quick response, remote and contactless control, harmless human-machine interaction and high economic efficiency. Under external magnetic actuation strategies, they are capable of achieving elaborate manipulation and navigation in extreme biomedical environments. This review focuses on state-of-the-art progresses in design strategies, fabrication techniques and applications of magnetically actuated micro/nanorobots.

Advanced Hand Gesture Prediction Robust to Electrode Shift with an Arbitrary Angle.

Recent advances in myoelectric controlled techniques have made the surface electromyogram (sEMG)-based sensing armband a promising candidate for acquiring bioelectric signals in a simple and convenient way. However, inevitable electrode shift as a non-negligible defect commonly causes a trained classifier requiring continuous recalibrations. In this study, a novel hand gesture prediction is firstly proposed; it is robust to electrode shift with arbitrary angle.

New Insight into Gap Electrospinning: Toward Meter-long Aligned Nanofibers.

Gap electrospinning is a facile technique to produce aligned nanofibers useful for many applications, but its potential has not yet been fully exploited in nature, leading to the fiber length still limited to several tens of centimeters at present. In this work, we report a breakthrough in the production of well-aligned nanofibers with record length and efficiency. Using a suitable poly(vinylidene fluoride) solution and a pair of parallel plates that are substrate-free and negatively connected, we demonstrate the ease of this technique to prepare length-controllable aligned fibers in a wide range (≤125 cm).

Identification and characterization of the erect-pose panicle gene EP conferring high grain yield in rice (Oryza sativa L.).

The breeding of japonica varieties with erect-pose panicle (EP) has recently progressed in the northern part of China, because these varieties exhibit a far higher grain yield than the varieties with normal-pose panicle (NP). A genetic analysis using the F(2) population from the cross between Liaojing5, the first japonica EP variety in China, and the Japanese japonica NP variety Toyonishiki revealed that EP is governed by a single dominant gene EP. Based on previous studies, map-based cloning of EP locus was conducted using Liaojing5, Toyonishiki, their F(2) population, and a pair of near-isogenic lines for EP locus (ZF14 and WF14) derived from the cross between the two varieties; consequently, the STS marker H90 was found to completely cosegregate with panicle pose.