Publications by authors named "Zhenhao Shao"
In the context of liver cirrhosis, the incidence of myocardial inflammation and apoptosis escalates, contributing to the development and progression of cirrhotic cardiomyopathy. The P2X7 receptor, a purinergic receptor linked to inflammatory processes, has been identified in the etiology of a range of autoinflammatory, autoimmune, chronic inflammatory, and metabolic disorders. Despite this, the specific role of the P2X7 receptor in the etiology of cirrhotic cardiomyopathy remains to be elucidated.
View Article and Find Full Text PDFArticle Synopsis
- Myocardial inflammation and cell death caused by cirrhosis contribute significantly to cirrhotic cardiomyopathy, with CD73 playing a potential role in these processes.
- In a mouse model of cirrhotic cardiomyopathy, researchers manipulated CD73 levels and observed its effects on heart function, inflammation, and cell death in the myocardium.
- The findings suggest that the increased expression of CD73 and activation of the A2A receptor help reduce inflammation and apoptosis in heart tissue by inhibiting the NF-κB pathway, providing insights into potential therapeutic targets.