Publications by authors named "Zhenhai Fu"

Diamagnetically levitated micro-nano oscillators play a crucial role in fundamental physics research and the advancement of high-precision sensors. Achieving high sensitivity in acceleration or force sensing is a fundamental requirement within these research domains. The primary limitation in achieving such sensitivity is thermal noise, which is directly proportional to the motion damping of the oscillator.

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Binary metal oxide stannate (MSnO; M = Zn, Mn, Co, etc.) structures, with their high theoretical capacity, superior lithium storage mechanism and suitable operating voltage, as well as their dual suitability for lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs), are strong candidates for next-generation anode materials. However, the capacity deterioration caused by the severe volume expansion problem during the insertion/extraction of lithium or sodium ions during cycling of MSnO-based anode materials is difficult to avoid, which greatly affects their practical applications.

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Optically levitated oscillators in high vacuum have excellent environmental isolation and low mass compared with conventional solid-state sensors, which makes them suitable for ultrasensitive force detection. The force resolution usually scales with the measurement bandwidth, which represents the ultimate detection capability of the system under ideal conditions if sufficient time is provided for measurement. However, considering the stability of a real system, a method based on the Allan variance is more reliable to evaluate the actual force detection performance.

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Recent advances in the field of optical tweezer technology have shown intriguing potential for applications in cardiovascular medicine, bringing this laboratory nanomechanical instrument into the spotlight of translational medicine. This article summarizes cardiovascular system findings generated using optical tweezers, including not only rigorous nanomechanical measurements but also multifunctional manipulation of biologically active molecules such as myosin and actin, of cells such as red blood cells and cardiomyocytes, of subcellular organelles, and of microvessels . The implications of these findings in the diagnosis and treatment of diseases, as well as potential perspectives that could also benefit from this tool, are also discussed.

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Article Synopsis
  • Optical trapping of nanoparticles in vacuum is important for precise measurements and fundamental physics, but determining the size and number of particles is challenging without a vacuum environment.
  • The study presents a new method for estimating nanoparticle size using scattering light from particles in an optical tweezer system, demonstrating experimental success in non-vacuum conditions.
  • This method shows strong agreement with existing theories and can preselect single particles from a mixed sample, making it useful for various types of nanoparticles and potentially aiding in the discovery of new scattering effects.
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Article Synopsis
  • A new ligand (HL) made up of 2-methyl quinoline-4-carboxylic acid, rhodamine, and naphthalene was created for detecting aluminum.
  • This ligand works as a ratiometric fluorescent sensor by using fluorescence resonance energy transfer (FRET) between naphthalimide and rhodamine.
  • When aluminum is added, there is a noticeable increase in fluorescence at 550 nm, while the emission at 524 nm decreases significantly.
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A dual-fiber optical trap system to trap and rotate a borosilicate microsphere has been proposed and experimentally demonstrated. The trapping system can be used as a probe to measure environmental parameters, such as torque, force, and viscosity of the surrounding medium. Under various conditions with different fiber misalignments, optical power, and fiber separation, the trapped sphere will exhibit three motion profiles including random oscillation, round rotation, and abnormal rotation.

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Two fluorescein-based chemosensors have been developed. They exhibited rapid and selective detection of 2,4,6-trinitrophenol (TNP) via fluorescence quenching both in ethanol and water solution when excited by visible light.

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Relay recognition of copper(ii) ions and biothiols via a fluorescence "on-off-on" cascade was designed and realized as a new sequential combination of cations and small molecules. Probe 1 bearing a fluorescein skeleton was thus synthesized, which performed well in 100% HEPES buffer (pH = 7.0) solution, as a highly sensitive, selective fluorescence sensor for Cu.

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A dual mode fluorescent probe, which is based on an integration of fluorescein and coumarin fluorophores, was developed for the discrimination of Cys from Hcy and GSH. This probe (2) shows the advantage of quick reaction (5 min) with Cys, resulting in a strong fluorescence turn-on response when excited at 450 nm. Notably, it also demonstrates the ratiometric fluorescence property while excited by a shorter wavelength (332 nm).

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