DNMT3b-mediated CpA methylation facilitates REST binding and gene silencing and exacerbates hippocampal demyelination in diabetic mice.

The remyelination process within the diabetes mellitus (DM) brain is inhibited, and dynamic interactions between DNA methylation and transcription factors are critical for this process. Repressor element-1 silencing transcription factor (REST) is a major regulator of oligodendrocyte differentiation, and the role of REST on DM remyelination remains to be investigated. Here, we investigated the effects of REST and DNA methylation on DM remyelination and explored the underlying mechanisms.

The GLCCI1/STAT3 pathway: a novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside.

Diabetic cognitive dysfunction (DCD) is a complication of diabetes that seriously affects quality of life. Glucocorticoid-induced transcript 1 (GLCCI1) has been found to be involved in inflammation, apoptosis and autophagy in various diseases. However, the distribution of GLCCI1 in the brain and its role in DCD have not yet been revealed.

Finite element study of the biomechanical effects on the rotator cuff under load.

Rotator cuff injuries account for 50% of shoulder disorders that can cause shoulder pain and reduced mobility. The occurrence of rotator cuff injury is related to the variation in shoulder load, but the mechanical changes in the rotator cuff caused by load remain unclear. Therefore, the mechanical results of the rotator cuff tissue during glenohumeral abduction and adduction were analyzed based on a finite element shoulder model under non-load (0 kg) and load (7.

Effect of different loads on the shoulder in abduction postures: a finite element analysis.

Load can change the mechanical environment of dynamic and static stable structures of the shoulder joint, increase the risk of tissue damage and affect the stability of the shoulder joint, but its biomechanical mechanism is still unclear. Therefore, a finite element model of the shoulder joint was constructed to analyze the mechanical index changes of shoulder joint abduction under different loads. The stress of the articular side on the supraspinatus tendon was higher than that of the capsular side, with a maximum difference of 43% due to the increased load.

Finite Element Analysis of Elbow Joint Stability by Different Flexion Angles of the Annular Ligament.

Objective: The injury of the annular ligament can change the stress distribution and affect the stability of the elbow joint, but its biomechanical mechanism is unclear. The present study investigated the biomechanical effects of different flexion angles of the annular ligament on elbow joint stability.

Methods: A cartilage and ligament model was constructed using SolidWorks software according to the magnetic resonance imaging results to simulate the annular ligament during normal, loosened, and ruptured conditions at different buckling angles (0°, 30°, 60°, 90°, and 120°).

Delayed radial head dislocation after radial shaft fracture fixation: a case report and review of the literature.

Background: Ipsilateral fracture of the radial shaft with dislocation of the radial head was a rare injury, but a delayed radial head dislocation after radial shaft fracture fixation was more extremely rare.

Case Presentation: A 39-year-old man fell from the height on his outstretched hand and injured his left, non-dominant forearm. Preoperative radiographs demonstrated a comminuted fracture of the proximal third of the radius but with no apparent dislocation of the distal or proximal radioulnar joints or the elbow.

Finite Element Analysis of Insertion Angle of Absorbable Screws for the Fixation of Radial Head Fractures.

Objective: To investigate the biomechanical effects of different insertion angles of absorbable screws for the fixation of radial head fractures.

Methods: The finite element models used to simulate the fractures were created based on CT scans. Two absorbable screws were used to fix and maintain the stability of the fracture, and the angles between the screws were set to 0°, 15°, 30°, 45°, 60°, 75°, and 90°.

Manipulating magnetoelectric properties by interfacial coupling in LaSrMnO/BaSrTiO superlattices.

Artificial superlattices constructed with ferromagnetic LaSrMnO layer and ferroelectric BaSrTiO layer were designed and fabricated on SrTiO substrates. An epitaxial growth with sharp interfaces between LaSrMnO and BaSrTiO layers was confirmed by scanning transmission electron microscopy and x-ray diffraction. An unambiguous charge transfer involving an electron transferring from the LaSrMnO layers to BaSrTiO layers (Mn→Mn; Ti→Ti) across the interface were resolved by electron energy loss spectra analysis.

Precisely Aligned Monolayer MoS Epitaxially Grown on h-BN basal Plane.

Control of the precise lattice alignment of monolayer molybdenum disulfide (MoS ) on hexagonal boron nitride (h-BN) is important for both fundamental and applied studies of this heterostructure but remains elusive. The growth of precisely aligned MoS domains on the basal plane of h-BN by a low-pressure chemical vapor deposition technique is reported. Only relative rotation angles of 0° or 60° between MoS and h-BN basal plane are present.

Degradation of monocrotophos by Starkeya novella YW6 isolated from paddy soil.

A bacteria strain, YW6, capable of utilizing monocrotophos (MCP) as the sole carbon and nitrogen sources for growth was isolated from paddy soil and identified as Starkeya novella. Strain YW6 completely degraded 0.2 mM MCP within 36 h without any lag period.

Alloyed semiconductor nanocrystals with broad tunable band gaps.

Nearly monodisperse alloyed (CuInS2)x(ZnS)1-x nanocrystals with cubic and hexagonal phases were successfully synthesized for the first time, and the band gaps of these alloyed nanocrystals can be tuned in the broad range of 1.5 to 3.7 eV by changing the ratio of CuInS2 to ZnS.

Synthesis of Cu-In-S ternary nanocrystals with tunable structure and composition.

Nearly monodisperse Cu-In-S ternary nanocrystals with tunable composition, crystalline structure, and size were synthesized by a hot-injection method using mixed generic precursors. Such ternary nanocrystals with zincblende and wurtzite structure were reported for the first time. This work correlates the crystalline structure of the binary ZnS nanoparticles with those of ternary Cu-In-S nanocrystals, demonstrating the feasibility of making their alloyed or core/shell structure.

Mesoporous carbon/silica nanocomposite through multi-component assembly.

Ordered mesoporous carbon/silica nanocomposites were synthesized through a novel multi-component molecular assembly and show promising potential as corrosion-resisted electrocatalyst supports.

Responsive periodic mesoporous polydiacetylene/silica nanocomposites.

Responsive PMO materials have been synthesized through co-assembly of bridged diacetylenic silsesquioxane and surfactant. The spatially defined polydiacetylenic component, mesoporous network, and the covalent proximity of polydiacetylene to silica endow the PMO with mechanical robustness, reversible chromatic responses, improved thermal stability, and faster responses to chemical stimuli. This research also provides an efficient molecular design and assembly paradigm to fabricate a family of conjugated optoelectronic materials, creating novel platforms for sensors, actuators, and other device applications.