Formal 1,1-Hydrocyanation Reaction of Alkynyl Halides with Isocyanides Enabled by Dual Nickel/Base Catalysis Relay.

We herein describe a formal 1,1-hydrocyanation reaction of alkynyl halides with isocyanides enabled by a dual nickel/base catalysis relay. -Butyl isocyanide serves as a "HCN" precursor that is introduced to the α-position of alkynyl halides, and the halogen atom is moved to the β-position. As a result, a series of ()-3-bromo/iodo acrylonitrile derivatives could be obtained in moderate yields.

ZIPK collaborates with STAT5A in p53-mediated ROS accumulation in hyperglycemia-induced vascular injury.

In this study we investigate the role of Zipper-interacting protein kinase (ZIPK) in high glucose-induced vascular injury, focusing on its interaction with STAT5A and its effects on p53 and inducible nitric oxide synthase (NOS2) expression. Human umbilical vein endothelial cells (HUVECs) are cultured under normal (5 mM) and high (25 mM) glucose conditions. Protein and gene expression levels are assessed by western blot analysis and qPCR respectively, while ROS levels are measured via flow cytometry.

Nickel-Catalyzed Cross-Coupling Reaction of Aryl Bromides/Nitriles with Imidazolium Salts Involving Inert C-N Bond Cleavage.

We herein present a nickel-catalyzed cross-coupling reaction of aryl halides and nitriles with imidazolium salts. A series of 2-arylated imidazoles could be obtained in moderate to good yields through inert C-N bond cleavage. The imidazolium salt in this reaction acts as both a coupling partner and -heterocyclic carbene (NHC) ligand precursor.