EGFR kinase domain duplication in lung adenocarcinoma with systemic and intracranial response to a double-dose of furmonertinib: a case report and literature review.

Background: EGFR kinase domain duplication (EGFR-KDD) is an infrequent oncogenic driver mutation in lung adenocarcinoma. It may be a potential target benefit from EGFR-tyrosine kinase inhibitors (TKIs) treatment.

Case Presentation: A 66-year-old Chinese male was diagnosed with lung adenocarcinoma in stage IVb with brain metastases.

Topical streptomycin irrigation of lesions to prevent postoperative site infections in spinal tuberculosis: a retrospective analysis.

Purpose: In spinal tuberculosis surgery, topical administration of drugs to the lesion is a preventive treatment measure. The aim is to achieve better bacterial inhibition and to prevent complications. As one of the most common complications after spinal tuberculosis surgery, many factors can lead to surgical site infection (SSI).

TransVG++: End-to-End Visual Grounding With Language Conditioned Vision Transformer.

In this work, we explore neat yet effective Transformer-based frameworks for visual grounding. The previous methods generally address the core problem of visual grounding, i.e.

Effects of Arginine-calcium carbonate pretreatment on the remineralizing and bonding performance of phosphorylated dentin.

Objectives: To evaluate the effects of Arginine-calcium carbonate (Arg-CaCO) paste treatment of phosphorylated dentin on remineralizing and bonding performance during direct and indirect restorations under pulpal pressure.

Methods: Under simulated pulpal pressure, dentin of healthy third molars were abraded and acid etched for 15s, then randomly divided into 4 groups: negative control group; Arg-CaCO group (1min); 2.5% Sodium trimetaphosphate (STMP) group (3min); S-A group, 2.

Molecular Biomarker Exploration of Rituximab plus CHOP Therapy in Real-World Diffuse Large B-Cell Lymphoma Patients.

Background: Presently, several classification methods are based on diffuse large B-cell lymphoma (DLBCL), but its clinical application has not yet been testified in Asian populations.

Methods: Twenty-five DLBCL patients were subjected to second-generation gene sequencing (NGS), and retrospective analysis of clinical features of the patients was to explore genotyping and survival prognosis biomarkers.

Results: The prevalent mutant genes in DLBCL patients cover myeloid differentiation factor 88 (MyD88) (40%), TP53 (32%), B-cell translocation gene 2 (BTG2) (28%), PIM1 (28%), and CREB-binding protein (CREBBP) (24%) in this study.

acts as a tumor suppressor in nasopharyngeal carcinoma by suppressing the AKT/GSK3β/β-catenin signaling pathway.

Unlabelled: Nasopharyngeal carcinoma (NPC) is a malignant tumor with a poor prognosis. Studies have shown that esophageal carcinoma related gene 4 (ECRG4) is hypermethylated and significantly downregulated in NPC tissues. However, the role of ECRG4 in NPC, and in particular the underlying molecular mechanism, is largely unclear.

A Practical Application for Quantitative Brain Fatigue Evaluation Based on Machine Learning and Ballistocardiogram.

Brain fatigue is often associated with inattention, mental retardation, prolonged reaction time, decreased work efficiency, increased error rate, and other problems. In addition to the accumulation of fatigue, brain fatigue has become one of the important factors that harm our mental health. Therefore, it is of great significance to explore the practical and accurate brain fatigue detection method, especially for quantitative brain fatigue evaluation.

Transformation of non-small cell lung cancer into small cell lung cancer in a patient with advanced lung cancer: a case report.

Targeted therapy in patients with epidermal growth factor receptor ()-mutated non-small cell lung cancer (NSCLC) often fails because of drug resistance. Here, we report a 57-year-old male patient with stage IV small cell lung cancer (SCLC) transformation during targeted therapy. Chest computerized tomography (CT), hematoxylin and eosin histological examination, immunohistochemistry, allele refractory mutation system-based quantitative polymerase chain reaction analysis of point mutations, and next-generation sequencing were performed for diagnosis and therapeutic efficacy evaluation.