Ultraviolet positioning via TDOA: error analysis and system prototype.

This work performs the design, real-time hardware realization, and experimental evaluation of a positioning system by ultra-violet (UV) communication under photon-level signal detection. The positioning is based on the time-difference of arrival (TDOA) principle. Time division-based transmission of synchronization sequence from three transmitters with known positions is applied.

Spread spectrum for covert communication in ultra-violet communication system.

In this paper, we propose a covert communication scheme based on a spread spectrum for ultra-violet communication. We first characterize the system model of the communication system, where Warden is adopted to monitor the legitimated user transmission based on the binary hypothesis test and Kolmogorov-Smirnov test. To avoid periodic transmission of the pilot sequence which potentially degrades covertness, we propose a blind synchronization approach, such that the pilot sequence does not need to be transmitted.

Paclitaxel prodrug nanoparticles boost antitumor efficacy via hitchhiking of human serum albumin.

Improving drug delivery efficacy is the key point for enhancing the therapeutic index of medicines. Herein, we report fatty chain conjugated paclitaxel (PTX) prodrugs with a disulfide bond as linker. The formed prodrugs can self-assemble into stable nanoparticles in aqueous solutions, and rapidly transform into long-circulating nanocomplexes via the non-covalent binding to serum albumin in blood, enabling efficient drug delivery and robust antitumor effect.

Clinical data and quantitative CT parameters combined with machine learning to predict short-term prognosis of severe COVID-19 in the elderly.

Rationale And Objectives: This study aims to evaluate the effectiveness of integrating clinical data and quantitative CT parameters with machine learning techniques in forecasting the short-term outcomes of severe COVID-19 in elderly patients.

Materials And Methods: In this retrospective study, we analyzed the clinical profiles and chest quantitative CT parameters of 239 elderly patients with severe COVID-19 admitted for treatment. The cohort included 61 deceased patients (death group) and 178 who recovered and were discharged (survival group).

Association between composite dietary antioxidant index and erectile dysfunction among American adults: a cross-sectional study.

Erectile dysfunction (ED) is closely related to oxidative stress, and antioxidant is a treatment and prevention method for erectile dysfunction. The Compound Dietary Antioxidant Index (CDAI) represents the overall dietary antioxidant intake of the human body. However, the link between CDAI and ED is unclear.

Highly Sensitive Detection of Tumor Cell-Derived Exosomes Using Solid-State Nanopores Assisted with a Slight Salt Gradient.

As an important biomarker, tumor cell-derived exosomes have substantial application prospects in early cancer screening and diagnosis. However, the unsatisfactory sensitivity and complicated sample pretreatment processes of conventional detection approaches have limited their use in clinical diagnosis. Nanopore sensors, as a highly sensitive, label-free, single-molecule technology, are widely utilized in molecule and bioparticle detection.

Value analysis of in the diagnostic and prognostic assessment of colorectal cancer.

Background: Colorectal cancer (CRC) remains the leading cause of cancer death worldwide. Less than half of the patients are diagnosed when the cancer is locally advanced. Several studies have shown that intelectin-1 () can serve as a key prognostic and therapeutic target for CRC.

Experimental investigation on backscattering interference cancellation for full-duplex UOWC based on time-reversal preprocessing.

A co-frequency and full-duplex (FD) underwater optical wireless communication (UOWC) system has the potential to significantly enhance spectral efficiency, reduce complexity, and further facilitate UOWC networking. However, the inevitable performance degradation due to self-interference introduced by backscattering presents a significant challenge. In this paper, we first experimentally explore the inherent characteristics of the underwater backscattering channel.

Experimental saturation characteristics of the PMT and adaptive compensation algorithm for OWC.

Orthogonal frequency division multiplexing (OFDM) utilizes numerous sub-carriers to achieve high transmission data rates. The frequency selectivity of the channel becomes a crucial factor influencing the communication performance of OFDM-based systems. In optical wireless communication (OWC) systems, the photomultiplier tube (PMT) may experience saturation when the incident optical power approaches its saturation threshold.

Analysis of the effect of cations on protein conformational stability using solid-state nanopores.

The conformation of proteins is closely related to their biological functions, and it is affected by many factors, including the type of cations in solution. However, it is difficult to detect the conformational changes of a protein . As a single-molecule sensing technology, nanopores can convert molecular structural information into analyzable current signals within a reasonable time range.

Association of socioeconomic status and overactive bladder in US adults: a cross-sectional analysis of nationally representative data.

Background: Socioeconomic status inequality is an important variable in the emergence of urological diseases in humans. This study set out to investigate the association between the prevalence of overactive bladder (OAB) and the poverty income ratio (PIR) that served as a more influential indicator of socioeconomic status compared to education and occupation.

Method: Data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2007 to 2020 were used in this cross-sectional study.

Specific pharmacological and G protein responses of some native GPCRs in neurons.

G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins and are important drug targets. The discovery of drugs targeting these receptors and their G protein signaling properties are based on assays mainly performed with modified receptors expressed in heterologous cells. However, GPCR responses may differ in their native environment.

LACC1 regulates changes in the intestinal flora in a mouse model of inflammatory bowel disease.

Background: The aim of this study was to explore the mechanism whereby LACC1 regulates the intestinal flora in a mouse model of inflammatory bowel disease (IBD).

Methods: C57BL/6 and Lacc1 mice were used to establish a mouse model of IBD induced by dextran sodium sulfate (DSS). The effects of Lacc1 deletion in mice were evaluated.

An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2/PTBP1 pan-adenocarcinoma.

In vitro-transcribed (IVT) mRNA has arisen as a rapid method for the production of nucleic acid drugs. Here, we have constructed an oncolytic IVT mRNA that utilizes human rhinovirus type 2 (HRV2) internal ribosomal entry sites (IRESs) to selectively trigger translation in cancer cells with high expression of EIF4G2 and PTBP1. The oncolytic effect was provided by a long hGSDMD-F1L mutant mRNA sequence with mitochondrial inner membrane cardiolipin targeting toxicity that triggers mitophagy.

Effects of underwater swing nodes on water-to-air visible light communication.

In water-to-air visible light communication (W2A-VLC), the dynamics of underwater nodes and a wavy water surface should not be neglected. This paper investigates the link performance by combining the dynamic effects of an underwater light-emitting diode (LED) transmitter with a wavy water surface. Monte Carlo simulation is first adopted to evaluate the underwater LED dynamics.

Endoplasmic reticulum stress-mediated autophagy alleviates lipopolysaccharide-induced nucleus pulposus cell pyroptosis by inhibiting CHOP signaling in vitro.

Pyroptosis, a newly discovered pro-inflammatory programmed necrosis of cells, serves as an initiating and promoting event that leads to intervertebral disc (IVD) degeneration (IDD). Endoplasmic reticulum stress (ERS) and autophagy are vital regulatory mechanisms of cellular homeostasis, which is also closely related to IDD. However, the role and relationship of ERS and autophagy in the pyroptosis of nucleus pulposus cell (NPC) are not well understood.

Optimizing the extraction of active components from by combination of machine learning models and intelligent optimization algorithms and its correlation analysis of antioxidant activity.

We extracted Sal B and TIIA from using enzymatic-assisted ethanol extraction. ACONN predicted optimal process conditions. Enzymolysis and alcohol extraction were used, optimizing conditions and evaluating antioxidant activity.

Ultraviolet communication with a large scattering angle via artificial agglomerate fog.

Considering strong signal attenuation of the large-angle non-line-of-sight (NLOS) link achieved due to the ultraviolet (UV) scattering properties, we propose to increase the UV communication link gain under a large scattering angle via generating agglomerate fog within a certain range as a secondary light source. In this study, a channel model with locally strong scatterers from agglomerate fog is proposed based on Monte Carlo ray-tracing approaches. Mie theory is adopted to calculate the atmospheric channel parameters, to further evaluate the link gain of a channel under non-uniform atmosphere.

Wide dynamic range signal detection for underwater optical wireless communication using a PMT detector.

In the underwater optical wireless communication (UOWC) scenario, a photomultiplier tube (PMT) with higher sensitivity, lower noise, and a larger receiver area is employed as the photon detector to further extend the transmission distance. Due to the complex underwater environment, the high directionality of the light beam, and the vibration of a transceiver, the incident optical power usually spans a very wide dynamic range, and the PMT may operate in any one of the three regimes: pulse, transition, and waveform. While it is difficult to obtain the analytical characterization of the output electric signals across these regimes, this paper resorts to experimental measurements of the upsampled discrete samples within a training symbol duration.

266 nm ultraviolet communication under unknown interference using UVC micro-LED.

Ultraviolet C (UVC) micro light-emitting diode (LED) can achieve symbol communication rate up to 100Msps at distance 40 meters without transmitter-side lens to guarantee certain communication mobility. We consider what we believe to be a new scenario where high speed UV communciation is realized under unknown low-rate interference. The signal amplitude properties are characterized, and the interference intensity is categorized into three cases, namely weak, medium and high interference intensity.

Pathological response and prognostic factors of neoadjuvant PD-1 blockade combined with chemotherapy in resectable oesophageal squamous cell carcinoma.

Purpose: We aimed to investigate the pathological changes, clinicopathological correlation and prognostic factors of neoadjuvant programmed cell death 1 (PD-1) blockade camrelizumab combined with carboplatin and nab-paclitaxel (CCNP) which we have proved its effectiveness in previous research for resectable esophageal squamous cell carcinoma (ESCC).

Methods: 108 patients of resectable ESCC, with a mean follow-up of 13 m (ranging 1-30 m), treated with neoadjuvant CCNP from March 2020 to October 2022 in the First Affiliated Hospital of Sun Yat-sen University were enrolled.

Results: One year overall survival (OS) and disease-free survival (DFS) were 96.

Multilevel polarization shift keying modulation for turbulence-robust underwater optical wireless communication.

Turbulence is an intractable issue for underwater optical wireless communication (UOWC). Most literature has been mainly focused on the modeling of turbulence channels and performance analysis rather than mitigation of the turbulence effect, especially from the experimental aspects. In this paper, a multilevel polarization shift keying (PolSK) modulation based UOWC system is established utilizing a 15 m-long water tank, and the system performance is investigated under specific temperature gradient-induced turbulence and various transmitted optical powers.

DIA-TTS: Deep-Inherited Attention-Based Text-to-Speech Synthesizer.

Text-to-speech (TTS) synthesizers have been widely used as a vital assistive tool in various fields. Traditional sequence-to-sequence (seq2seq) TTS such as Tacotron2 uses a single soft attention mechanism for encoder and decoder alignment tasks, which is the biggest shortcoming that incorrectly or repeatedly generates words when dealing with long sentences. It may also generate sentences with run-on and wrong breaks regardless of punctuation marks, which causes the synthesized waveform to lack emotion and sound unnatural.

Bi-directional ultra-violet communication with self-interference.

We investigate the self-interference characterization, achievable rate, signal detection and parameter estimation for bi-directional ultra-violet (UV) communication. We firstly characterize and experimentally demonstrate the self-interference of UV communication, which is non-negligible as the angle between the transmission and receiver directions is blow 60°. Then, we present the achievable rate and symbol detection under self-interference, which show that the offset between self-interference and desirable symbols can increase the achievable rate and decrease the symbol detection error probability.

Anti error and erasure coding for water-to-air visible light communication through wavy water surface with wave height up to 0.6 meters.

Considering large dynamic optical intensity range in a water-to-air (W2A) channel, we propose two promising channel coding schemes, namely the concatenated Reed Solomon-Low Density Parity Check (RS-LDPC) code and Raptor code, for W2A visible light communication (VLC). We establish a W2A-VLC link to verify the performance under different wavy water environments and different water depths with a green light emitting diode (LED). A wave generator is adopted to emulate the wavy water surface with wave height up to 0.