Synopsis of recent research by authors named "Zhengyu Zha"
- Zhengyu Zha's research predominantly focuses on the molecular mechanisms underlying cancer, particularly in lung adenocarcinoma and non-small cell lung cancer (NSCLC), exploring cellular heterogeneity and resistance to therapies, as evidenced by identifying multicellular ecotypes and the role of TET2 in TKI resistance.
- His findings include the characterization of lung multicellular ecotypes that reflect distinct cancer stages and the impact of TET2 deficiency on the efficacy of EGFR-targeted therapies, suggesting potential targets for overcoming resistance in NSCLC patients.
- Zha’s work also extends to investigating the interactions of immunoregulatory pathways, highlighting the IL-6/JAK1 pathway's role in immune evasion and exploring therapeutic targets such as ROS1 in hepatocellular carcinoma, thereby contributing to the understanding of tumor immune dynamics and treatment strategies.
