Publications by authors named "Zhengyu Qian"
The intestinal microbiota community is a fundamental component of the human body and plays a significant regulatory role in maintaining overall health and in the management disease states.The intestinal microbiota-gut-brain axis represents a vital connection in the cognitive regulation of the central nervous system by the intestinal microbiota.The impact of intestinal microbiota on cognitive function is hypothesized to manifest through both the nervous system and circulatory system.
View Article and Find Full Text PDFPatients with high tumor mutational burden (TMB) levels do not consistently respond to immune checkpoint inhibitors (ICIs), possibly because a high TMB level does not necessarily result in adequate infiltration of CD8 T cells. Using bulk ribonucleic acid sequencing (RNA-seq) data from 9311 tumor samples across 30 cancer types, we developed a novel tool called the modulator of TMB-associated immune infiltration (MOTIF), which comprises genes that can determine the extent of CD8 T cell infiltration prompted by a certain TMB level. We confirmed that MOTIF can accurately reflect the integrity and defects of the cancer-immunity cycle.
View Article and Find Full Text PDFAbstract: The grand challenge of "net-zero carbon" emission calls for technological breakthroughs in energy production. The traveling wave reactor (TWR) is designed to provide economical and safe nuclear power and solve imminent problems, including limited uranium resources and radiotoxicity burdens from back-end fuel reprocessing/disposal. However, qualification of fuels and materials for TWR remains challenging and it sets an "end of the road" mark on the route of R&D of this technology.
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- Myogenic differentiation is crucial for muscle regeneration and atrophy, and this study investigates the role of crotonylation, a posttranslational modification, in this process.
- Using C2C12 cells and mouse models, researchers discovered that crotonylation levels decline during muscle differentiation and identified specific interactions involving the protein AKT1 that impact its function.
- The findings suggest that reducing AKT1 crotonylation enhances its phosphorylation, promoting muscle differentiation, which could provide insights into muscle injury repair and conditions like sarcopenia.
The thymus is a vital organ of the immune system that plays an essential role in thymocyte development and maturation. Thymic atrophy occurs with age (physiological thymic atrophy) or as a result of viral, bacterial, parasitic or fungal infection (pathological thymic atrophy). Thymic atrophy directly results in loss of thymocytes and/or destruction of the thymic architecture, and indirectly leads to a decrease in naïve T cells and limited T cell receptor diversity.
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- - Human African trypanosomiasis (HAT), caused by the Trypanosoma brucei species, caused major epidemics in the 20th century but has seen a significant drop in cases due to effective control programs.
- - Despite fewer than 977 reported cases in endemic countries in 2018, HAT remains a public health concern, with almost 150 cases found in non-endemic areas, mainly in Europe, the USA, and South Africa, often linked to historical or economic ties.
- - The paper examines HAT incidence data and reveals no correlation between cases in endemic and non-endemic countries, providing insights into understanding imported cases of HAT in the context of global health post-elimination efforts