Publications by authors named "Zhengxuan Gu"
Article Synopsis
- Enzymes are typically used in biosensing for signal amplification, but their performance can vary with changes in the environment, like pH and temperature.
- The new approach, called activity-independent enzyme-powered (AIEP) amplification, aims to stabilize and improve signal quality without relying on enzyme activity during the biosensing process.
- The method was tested by monitoring oxidative stress in drug-induced liver injury, showing that it effectively evaluates hepatoprotective effects using a specific fluorophore and a degradation-triggered nanobeacon.
Fertilization and early embryonic development as the beginning of a new life are key biological events. Hydrogen polysulfide (H S ) plays important roles during physiological regulation, such as antioxidation-protection. However, no report has studied in situ H S fluctuation during early embryonic development because of the low abundance of H S and inadequate sensitivity of probes.
View Article and Find Full Text PDFFor sensing low abundance of biomarkers, utilizing nanocarriers to load dyes is an efficient method to amplify the detected signal. However, the non-specific leak of the internal dyes in this approach is accompanied by false positive signals, resulting in inaccurate signal acquirement. To address this issue, in this work, we reported a novel signal amplification strategy with dye as a scaffold to construct a self-immolative dye-doped polymeric probe (SDPP).
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