Global research trends on biomarkers for cancer immunotherapy: Visualization and bibliometric analysis.

The global burden of cancer continues to grow, posing a significant public health challenge. Although cancer immunotherapy has shown significant efficacy, the response rate is not high. Therefore, the objective of our research was to identify the latest research trends and hotspots on biomarkers from 1993 to 2023.

Facile synthesis and anion binding properties of a preorganized macrocyclic receptor.

Herein, we report a novel Schiff base macrocyclic receptor (MR). The structure of MR was characterized by NMR, UV-vis and fluorescence spectroscopy, revealing that it was a rigid and preorganized planar π-conjugated fluorescent macrocycle. Furthermore, MR showed effective binding properties with tetrabutylammonium halides TBAX (X = Cl, Br, and I) which were investigated by the NMR titration method and molecular modelling.

Charge-transfer inclusion complex formation of the tropylium cation with prism[6]arenes.

Herein, we report that prism[6]arenes (PrS[6]R) can form charge-transfer (CT) inclusion complexes with tropylium tetrakis[3,5-bis(trifluoromethyl)-phenyl]borate (G) in chloroform solution with an obvious CT band at 560 nm. Moreover, the CT complex PrS[6]Et⊃G showed Cl/Ag responsiveness which can be easily monitored by the naked eye.

Emplacement of the Argyle diamond deposit into an ancient rift zone triggered by supercontinent breakup.

Argyle is the world's largest source of natural diamonds, yet one of only a few economic deposits hosted in a Paleoproterozoic orogen. The geodynamic triggers responsible for its alkaline ultramafic volcanic host are unknown. Here we show, using U-Pb and (U-Th)/He geochronology of detrital apatite and detrital zircon, and U-Pb dating of hydrothermal titanite, that emplacement of the Argyle lamproite is bracketed between 1311 ± 9 Ma and 1257 ± 15 Ma (2σ), older than previously known.

Exploring the Molecular Mechanism of HongTeng Decoction against Inflammation based on Network Analysis and Experiments Validation.

Background: HongTeng Decoction (HTD) is a traditional Chinese medicine that is widely used to treat bacterial infections and chronic inflammation. However, its pharmacological mechanism is not clear. Here, network pharmacology and experimental verification were applied to investigate the drug targets and potential mechanisms of HTD in inflammation treatment.

Research trends of acupuncture therapy on dysmenorrhea from 2002 to 2022: A bibliometric analysis.

This research wasdesigned to provide a visual analysis of the current status, hotspots, and trends of global acupuncture for dysmenorrhea over the past 2 decades. The literature about acupuncture for dysmenorrhea from the Web of Science Core Collection database. Cite Space (5.

Why supercontinents became shorter lived as the Earth evolved.

Periodic assembly and break-up of supercontinents since at least two billion years ago (Ga), dubbed the supercontinent cycle, provides the first-order tectonic control on the evolution of the Earth System including episodic orogenic events, mineralization, the formation and closure of oceans and superoceans, and even the evolution of life. However, the lifespan of the supercontinents appears to decrease with time, from ∼300 million years (Myr) for Nuna/Columbia, to 200-250 Myr for Rodinia and ∼150 Myr for the youngest supercontinent Pangaea. To understand what caused such a secular decrease in supercontinental lifespan, we conduct 3-D geodynamic modeling using realistic tectonic settings.

Will Earth's next supercontinent assemble through the closure of the Pacific Ocean?

Earth's known supercontinents are believed to have formed in vastly different ways, with two endmembers being introversion and extroversion. The former involves the closure of the internal oceans formed during the break-up of the previous supercontinent, whereas the latter involves the closure of the previous external superocean. However, it is unclear what caused such diverging behavior of supercontinent cycles that involved first-order interaction between subducting tectonic plates and the mantle.

Construction and Comprehensive Analysis of ceRNA Networks and Tumor-Infiltrating Immune Cells in Hepatocellular Carcinoma With Vascular Invasion.

Hepatocellular carcinoma (HCC) is a common malignant cancer. Metastasis plays a critical role in tumor progression, and vascular invasion is considered one of the most crucial factors for HCC metastasis. However, comprehensive analysis focusing on competitive endogenous RNA (ceRNA) and immune infiltration in the vascular invasion of HCC is lacking.

Flame atomic absorption spectrometry combined with surface-modified magnetic mesoporous silica microspheres by polyethyleneimine for enrichment, isolation and determination of Cu in preserved eggs after high-temperature digestion.

A new efficient magnetic solid-phase extractant based on a surface-modified magnetic mesoporous silica microsphere referred as MMSM-PEI was synthesised and used for the enrichment and isolation of copper ions (Cu) in preserved eggs. The physicochemical properties and morphology of MMSM-PEI were characterized by X-ray diffraction (XRD) spectroscopy, Fourier transform infrared spectroscopy (FT-IR), vibration sample magnetometry (VSM), scanning electron microscopy (SEM) and thermos-gravimetric analyses (TGA). The concentrations of trace Cu in the preserved egg were determined by flame atomic absorption spectroscopy (FAAS).

Development, validation, and clinical application of a rapid UPLC-MS/MS method for detection of colchicine in human whole blood and urine.

A rapid, simple, and economical method has been developed to determine colchicine in both human whole blood and urine using UPLC-MS/MS. Colchicine and isotope-labeled internal standard were extracted from the matrix by liquid-liquid extraction with saturated borax and ethyl acetate, and separated by a reversed-phase chromatography C18 column. Gradient elution was carried out using acetonitrile and water spiked with 0.

Diammonium Glycyrrhizinate Ameliorates Obesity Through Modulation of Gut Microbiota-Conjugated BAs-FXR Signaling.

Obesity is a worldwide epidemic metabolic disease. Gut microbiota dysbiosis and bile acids (BAs) metabolism disorder are closely related to obesity. Farnesoid X-activated receptor (FXR), served as a link between gut microbiota and BAs, is involved in maintaining metabolic homeostasis and regulating glucose and lipid metabolism.

Oceanic and super-deep continental diamonds share a transition zone origin and mantle plume transportation.

Rare oceanic diamonds are believed to have a mantle transition zone origin like super-deep continental diamonds. However, oceanic diamonds have a homogeneous and organic-like light carbon isotope signature (δC - 28 to - 20‰) instead of the extremely variable organic to lithospheric mantle signature of super-deep continental diamonds (δC - 25‰ to + 3.5‰).

Heavy metals in bamboo shoots from Southeastern China and risk assessment.

Bamboo shoot is an indispensable vegetable in Southeastern China, so a survey of heavy metals in bamboo shoots is a relevant topic of interest. The present study sought to analyse the content of seven heavy metals (As, Cd, Cr, Cu, Mn, Pb and Zn) in six bamboo shoot species from Southeastern China. Percentages of 3.

Efficacy and safety of proton pump inhibitors combined with clopidogrel in patients undergoing percutaneous coronary intervention: a meta-analysis.

Our objective was to systematically evaluate the efficacy and safety of proton pump inhibitors combined with clopidogrel in patients undergoing percutaneous coronary intervention and to provide an evidence basis for clinical treatment decision-making. The database EMBASE, PubMed/Medline, Web of Science, the Cochrane Library and CNKI records from establishment of each database until August 2020 were included. Articles were evaluated for quality.

Epidemiology and determinants of clonorchiasis in school children in southeastern China.

Clonorchiasis is an important food-borne parasitic disease in China because of the popularity in ingesting raw freshwater fish. To explore the epidemiology and determinants of clonorchiasis in children, a cross-sectional survey was implemented in two middle schools in Qiyang county, Hunan province, in southeastern China. Questionnaire survey and fecal examination were implemented.

Geochemical evidence for a widespread mantle re-enrichment 3.2 billion years ago: implications for global-scale plate tectonics.

Progressive mantle melting during the Earth's earliest evolution led to the formation of a depleted mantle and a continental crust enriched in highly incompatible elements. Re-enrichment of Earth's mantle can occur when continental crustal materials begin to founder into the mantle by either subduction or, to a lesser degree, by delamination processes, profoundly affecting the mantle's trace element and volatile compositions. Deciphering when mantle re-enrichment/refertilization became a global-scale process would reveal the onset of efficient mass transfer of crust to the mantle and potentially when plate tectonic processes became operative on a global-scale.

Author Correction: Global geochemical fingerprinting of plume intensity suggests coupling with the supercontinent cycle.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

A Comparative Study on the Health Status and Behavioral Lifestyle of Centenarians and Non-centenarians in Zhejiang Province, China-A Cross-Sectional Study.

The growth rate of centenarians was unusually rapid in recent decades, ushering in an era of longevity. This study aims to explore the difference between centenarians and non-centenarians using quantitative research, and to scientifically guide residents to develop the correct lifestyle and health care ways. From October 2013 to August 2017.

Global geochemical fingerprinting of plume intensity suggests coupling with the supercontinent cycle.

Plate tectonics and mantle plumes are two of the most fundamental solid-Earth processes that have operated through much of Earth history. For the past 300 million years, mantle plumes are known to derive mostly from two large low shear velocity provinces (LLSVPs) above the core-mantle boundary, referred to as the African and Pacific superplumes, but their possible connection with plate tectonics is debated. Here, we demonstrate that transition elements (Ni, Cr, and Fe/Mn) in basaltic rocks can be used to trace plume-related magmatism through Earth history.

Cr-spinel records metasomatism not petrogenesis of mantle rocks.

Mantle melts provide a window on processes related to global plate tectonics. The composition of chromian spinel (Cr-spinel) from mafic-ultramafic rocks has been widely used for tracing the geotectonic environments, the degree of mantle melting and the rate of mid-ocean ridge spreading. The assumption is that Cr-spinel's core composition (Cr# = Cr/(Cr + Al)) is homogenous, insensitive to post-formation modification and therefore a robust petrogenetic indicator.

UC Unit in Fullerenes: Robust Multicenter Bonds with a Cluster Shape Controlled by Cage Size and Charge Transfer.

Stimulated by the recent successful synthesis and crystallographic characterization of the first diuranium carbide endohedral metallofullerene (EMF) UC@(7)-C ( Zhang et al. ; 2018 ), density functional theory calculations were performed for a series of UC@C (2 = 60, 68, 72, 78, 80, 88, 96, and 104) analogues. The internal UCU bond angle increases from 96.