Publications by authors named "Zhengtao Yong"
Article Synopsis
- Photodynamic therapy (PDT) is effective in killing tumor cells and provoking immune responses, but its effectiveness is often limited by antioxidant systems like glutathione (GSH) and thioredoxin (Trx).
- A new nanomedicine (PtHPs) was developed that combines a photosensitizer (PPa) and a cisplatin prodrug (Pt(IV)) using hydroxyethyl starch (HES) to inhibit these antioxidant systems and enhance PDT's effectiveness.
- In tests, PtHPs demonstrated improved tumor-killing capabilities, increased reactive oxygen species (ROS) production, and promoted immune responses, leading to significant tumor suppression in various models with good safety outcomes.
Article Synopsis
- - The study explores how tumor cells' antioxidant systems, primarily glutathione and thioredoxin networks, reduce the effectiveness of photodynamic therapy (PDT) and hinder anti-tumor immune responses.
- - A new nanodisruptor called Phy@HES-IR is designed to enhance PDT by inhibiting key pathways in tumor cells that produce antioxidants, leading to better drug delivery and increased PDT efficacy.
- - The combined effects of PDT and metabolic changes trigger immunogenic cell death, which not only helps in reducing primary tumor growth but also activates a strong immune response against distant tumors in mice.
Tumor starvation induced by intratumor glucose depletion emerges as a promising strategy for anticancer therapy. However, its antitumor potencies are severely compromised by intrinsic tumor hypoxia, low delivery efficiencies, and undesired off-target toxicity. Herein, a multifunctional cascade bioreactor (HCG), based on the self-assembly of pH-responsive hydroxyethyl starch prodrugs, copper ions, and glucose oxidase (GOD), is engineered, empowered by hyperbaric oxygen (HBO) for efficient cooperative therapy against aggressive breast cancers.
View Article and Find Full Text PDFThe application of photodynamic therapy (PDT) is limited by tumor hypoxia. To overcome hypoxia, catalase-like nanozymes are often used to catalyze endogenous HO enriched in tumor tissues to O. Nonetheless, the catalase activity may not be optimal at body temperature and the O supply may not meet the rapid O consumption of PDT.
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