Detecting Changes in Singlet Oxygen and Viscosity during Apoptosis-Ferroptosis Mediated Photodynamic Therapy and Establishing Visual Imaging of Fatty Liver.

Cancer is a serious global health threat, and photodynamic therapy (PDT) is an effective treatment method for cancer. This therapy works by generating a large amount of singlet oxygen (O) under the influence of oxygen and light, which induces apoptosis in tumor cells, leading to their destruction. However, the resistance of cells to apoptosis limits the development of PDT, and thus the combination of ferroptosis and apoptosis provides a new perspective for PDT.

12-O-tetradecanoylphorbol-13-acetate (TPA) increases murine intestinal crypt stem cell survival following radiation injury.

Radiation enteropathy is a common complication in cancer patients following radiation therapy. Thus, there is a need for agents that can protect the intestinal epithelium against radiation. 12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce differentiation and/or apoptosis in multiple cell lines and primary cells.

Synergistic interactions between 12-0-tetradecanoylphorbol-13-acetate (TPA) and imatinib in patients with chronic myeloid leukemia in blastic phase that is resistant to standard-dose imatinib.

We have demonstrated that 12-0-tetradecanoylphorbol-13-acetate (TPA) combined with vitamin D(3) (VD(3)) and cytosine arabinoside (Ara C) is effective and feasible for chronic myelogenous leukemia (CML) in blastic phase (BP). In the current study, the efficacy of TPA combined with inhibitor imatinib mesylate (imatinib) was investigated in patients with CML in BP that was resistant to standard-dose imatinib (400mg/day). The results suggested that TPA combined with imatinib (400mg/day) might overcome disease-poor response to conventional doses.