Nanomaterials in Medicine: Understanding Cellular Uptake, Localization, and Retention for Enhanced Disease Diagnosis and Therapy.

Nanomaterials (NMs) have emerged as promising tools for disease diagnosis and therapy due to their unique physicochemical properties. To maximize the effectiveness and design of NMs-based medical applications, it is essential to comprehend the complex mechanisms of cellular uptake, subcellular localization, and cellular retention. This review illuminates the various pathways that NMs take to get from the extracellular environment to certain intracellular compartments by investigating the various mechanisms that underlie their interaction with cells.

Research progress on nanotechnology of traditional Chinese medicine to enhance the therapeutic effect of osteoarthritis.

Osteoarthritis (OA) is a prevalent chronic condition that primarily impacts the articular cartilage and surrounding bone tissue, resulting in joint inflammation and structural deterioration. The etiology of OA is multifaceted and intricately linked to the oxidative stress response of joint tissue. Oxidative stress (OS) in OA leads to the creation of reactive oxygen species (ROS) and other oxidizing agents, resulting in detrimental effects on chondrocytes.

Screening and Discrimination of Perfluoroalkyl Substances in Aqueous Solution Using a Luminescent Metal-Organic Framework Sensor Array.

The extensive production and large-scale use of perfluoroalkyl substances (PFASs) have raised their presence in aquatic environments worldwide. Thus, the facile and reliable screening of PFASs in aqueous systems is of great significance. Herein, we designed a novel fluorescent sensor array for the rapid screening and discrimination of multiple PFASs in water.

Insights into Uptake, Translocation, and Transformation Mechanisms of Perfluorophosphinates and Perfluorophosphonates in Wheat ( L.).

As emerging alternatives of legacy perfluoroalkyl substances, perfluorophosphinates (PFPiAs) and perfluorophosphonates (PFPAs) are widely applied in industrial and agricultural fields and are supposed to be large partitioned to soil and highly persistent. It is of particular interest to understand their transfer from roots to shoots and transformation in plants, such as wheat. The results of hydroponic experiments indicated that C6/C6 PFPiA, C8/C8 PFPiA, perfluorooctanophosphonic acid (PFOPA), and perfluorohexaphosphonic acid (PFHxPA) were quickly adsorbed on the epidermis of wheat root ( L.

High frequency discharge plasma induced plasticizer elimination in water: Removal performance and residual toxicity.

Plasticizers are widely present in water and soil environment, and they can bring enormous threats to environmental safety and human health. A discharge plasma system driven by a high-frequency electric source was used to remove the plasticizer from wastewater; and dimethyl phthalate (DMP) was chosen as the representative of plasticizer. DMP elimination performance at various operating parameters, roles of active species in DMP degradation, DMP decomposition process, and its residual toxicity after decomposition were systematically investigated.