Publications by authors named "Zhengri Li"
Background: To compare the efficacy of 0.15% hyaluronic acid (HA), 0.05% cyclosporine A (CsA) and 3% diquafosol sodium (DQS) ophthalmic solution for the treatment of moderate-to-severe dry eye disease (DED) in college students and the effect on inflammatory factors in tears.
View Article and Find Full Text PDFPurpose: To investigate dynamic pupil changes after orbital blowout fracture repair. To compare postoperative changes in under photopic and mesopic pupil size and center position after orbital blowout fracture repair surgery.
Methods: The study evaluated 19 eyes.
Impaired oxidation of clozapine has been reported in steatotic rat liver due to downregulation of cytochrome P450 (CYP) 1A. Pharmacokinetic changes of clozapine and its major metabolite, norclozapine, were evaluated in a rat model of non-alcoholic fatty liver disease (NAFLD) induced by orotic acid. Significantly slower CL for formation of norclozapine from clozapine was observed in NAFLD rats than in control rats as a result of the reduced protein expression and metabolic activity of CYP1A1/2.
View Article and Find Full Text PDFPurpose: To analyze the distribution of the offset between the pupil center and the coaxially sighted corneal light reflex (), the effects of 50% and 100% angle kappa adjustments on refractive and visual quality in patients with moderate myopia were investigated.
Methods: A randomly selected 254 patients (254 eyes) with moderate myopia who underwent femtosecond laser-combined LASIK were examined. During the operation, the of the patients was recorded by the and y-axis eyeball-tracking adjustment program of the WaveLight Eagle Vision EX500 excimer laser system.
Purpose: To investigate expression and role of nucleotide-binding oligomerization domain 2 (NOD2) in the ocular surface of experimental dry eye (EDE), which is a nod-like receptor member and is involved in innate immune response.
Methods: C57/BL6 female mice were divided into the groups: untreated (UT), EDE, and NOD2 knockout (KO) mice exposed to desiccating stress for 14 days. Clinical parameters and levels of inflammatory cytokine were measured at 3,5,7, and 14 days.
Purpose: Preliminary study results have shown that rats with non-alcoholic fatty liver disease (NAFLD) induced by 1% orotic acid-containing diet have decreased hepatic CYP2D activity. This study aims to evaluate the possible pharmacokinetic changes in NAFLD as a result of reduced metabolic activity of CYP2D.
Methods: The pharmacokinetics of metoprolol and its metabolites, O-desmethyl metoprolol (DMM) and α-hydroxy metoprolol (HM), was investigated in NAFLD and control rats following intravenous (1 mg/kg) and oral (2 mg/kg) administration of metoprolol.
Purpose: To investigate the expression pattern of nucleotide-binding oligomerization domain (Nod)-like receptors that detects "danger" intracellular signaling and its correlation with clinical dry eye (DE) markers.
Design: Cross-sectional study.
Methods: A total of 50 participants with 50 eyes were included: 23 eyes with Sjögren syndrome (SS)-DE, 14 eyes with non-SS-DE, and 13 healthy controls with non-DE.
Purpose: The aim of this study was to explore the relationship between chronic cigarette smoking and meibomian gland dysfunction (MGD).
Methods: This study enrolled 322 smokers with MGD and 2067 non-smokers with MGD. All enrolled subjects were tested in the following sequence: Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), corneal fluorescein staining (CFS), Schirmer I test (SIT)and finally slit-lamp microscope examination of lid margin abnormalities, meibomian gland expression as well as meibum.
Purpose: To investigate the influence of overexposure to light emitting diode (LED)-derived light with various wavelengths on mouse ocular surface.
Methods: LEDs with various wavelengths were used to irradiate C57BL/6 mice at an energy dose of 50 J/cm2, twice a day, for 10 consecutive days. The red, green, and blue groups represented wavelengths of 630 nm, 525 nm, and 410 nm, respectively.
Purpose. To investigate the therapeutic effects of topical administration of antioxidant medicinal plant extracts in a mouse model of experimental dry eye (EDE). Methods.
View Article and Find Full Text PDFPurpose: To investigate the wound healing effect of adiponectin eye drops following corneal alkali burn.
Materials And Methods: A chemical burn was induced using 0.1 M NaOH in both adenovirus 12-SV40 hybrid-transformed human corneal epithelial (HCE-2) cells and C57BL/6 mice.
Article Synopsis
- The study aimed to evaluate the effectiveness of AICAR eye drops in treating experimental dry eye in mice.
- Mice treated with 0.01% AICAR showed significant improvements in tear production, eye health, and reductions in inflammatory markers compared to control groups.
- This suggests that AICAR could be a promising new treatment for dry eye disease.
Purpose: To investigate the therapeutic effects of mineral oil (MO) and hyaluronic acid (HA) mixture eye drops on the tear film and ocular surface in a mouse model of experimental dry eye (EDE).
Methods: Eye drops consisting of 0.1% HA alone or mixed with 0.
Purpose: To investigate the effects of visible light on human corneal epithelial cells and the impact of natural antioxidants on oxidative stress produced by overexposure to light.
Methods: Light-emitting diodes with various wavelengths (410-830 nm) were used to irradiate human corneal epithelial cells, and cell viability was assessed. The production of reactive oxygen species (ROS) was analyzed using 2',7'-dichlorodihydrofluorescein diacetate (DCF-DA).
Purpose: To investigate the efficacy of hypotonic 0.18% sodium hyaluronate (SH) eyedrops in a mouse model of experimental dry eye (EDE).
Methods: EDE was induced in C57BL/6 mice by a subcutaneous scopolamine injection and an air draft.
Purpose: To investigate the efficacy of the topical application of omega-3 essential fatty acids (EFAs) and hyaluronic acid (HA) mixtures in a mouse model of experimental dry eye (EDE).
Methods: Eye drops consisting of 0.1% HA, 0.
Therapeutic effect of topical adiponectin in a mouse model of desiccating stress-induced dry eye.
Invest Ophthalmol Vis Sci
January 2013
Purpose: To investigate the therapeutic effect of topical adiponectin in a mouse model of experimental dry eye (EDE).
Methods: EDE was created by desiccating stress in 6- to 8-week old female C57BL/6 mice. Eye drops consisting of 0.
Purpose: To investigate the efficacy of a topical anti-tumor necrosis factor-α agent, infliximab, in a mouse model of experimental dry eye (EDE).
Methods: EDE was induced in C57BL/6 mice, with or without topical treatment consisting of balanced salt solution or 0.001%, 0.
Article Synopsis
- The study aimed to assess the effectiveness of umbilical cord serum (UCS) eye drops on corneal healing and haze in mice with chemical burns, comparing them to peripheral blood serum (PBS) and artificial tears (AT).
- The results indicated that the UCS eye drops led to faster healing of corneal wounds and less haze compared to both PBS and AT at various time points during the treatment.
- Histological analysis confirmed that UCS-treated mice had better epithelial integrity and lower inflammation, and UCS also resulted in lower levels of a specific inflammatory marker (IL-1β) compared to PBS.*
Wasp sting of the cornea: a case treated with amniotic membrane transplantation.
Graefes Arch Clin Exp Ophthalmol
March 2013
Objective: To investigate the effect of hyperglycemia on the expression of the aquaporin (AQP) isoforms in the diabetic rat vagina.
Methods: Female Sprague-Dawley rats (230-240 g, n = 45) were divided into control (n = 10) and experimental (n = 35) groups. Diabetes in the experimental group was induced by intraperitoneal injection of streptozotocin (STZ, 65 mg/kg).
Purpose: To evaluate the expression of CXCL9, -10, and -11 chemokines in the aqueous humor of patients with herpetic endotheliitis.
Methods: Aqueous humor was collected from 26 patients with herpetic endotheliitis and 21 control subjects. The concentrations of CXCL9, -10, and -11 in the aqueous humor were measured with enzyme-linked immunosorbent assays.
Purpose: To evaluate the expression of CCR5 and its ligands CCL3, CCL4, and CCL5 in the tear film and ocular surface and their correlation with disease severity in patients with dry eye disease.
Materials And Methods: The concentrations of CCL3, CCL4, and CCL5 were measured using enzyme-linked immunosorbent assay in tear samples obtained from forty-three patients with dry eye (17 SS and 26 non-SS patients) and 20 control subjects. The correlation between chemokine levels and tear film and ocular surface parameters was analyzed.
Tear production and ocular surface changes in experimental dry eye after elimination of desiccating stress.
Invest Ophthalmol Vis Sci
September 2011
Purpose: To investigate the severity and duration of desiccating stress-induced dry eye disease between mice with and without a genetic predisposition to spontaneous autoimmunity.
Methods: Experimental dry eye was induced in 12- to 16-week-old wild-type C57BL/6 and autoimmune NOD.B10.