Clinical Features of Hepatic Manifestations among Adult Patients with Hemophagocytic Lymphohistiocytosis: A Retrospective Study.

Introduction: Liver dysfunction is common in patients with hemophagocytic lymphohistiocytosis (HLH). However, whether the severity of liver injury is associated with the prognosis of patients with HLH remains to be determined. This study aims to assess the association of the severity of liver involvement with short-term prognosis among adult patients with HLH.

The application and effect of predictive nursing in the prevention of accidental events during operations for SMI patients.

Objective: To explore the status and influencing factors of job burnout among psychiatric nurses and provide a reference for hospital managers to carry out occupational and psychological interventions.

Methods: Between September 2021 and September 2022, the psychiatric nurses in Wuhan Wudong Hospital (Wuhan Second Psychiatric Hospital) were selected as research participants using convenience sampling. The Chinese version of the nursing burnout scale was used to investigate the psychiatric nurses in the hospital, and a multiple linear regression analysis was performed on the factors affecting job burnout.

EPC infusion ameliorates acute graft-versus-host disease-related endothelial injury after allogeneic bone marrow transplantation.

Introduction: Graft-versus-host disease (GVHD) damages vascular endothelium. Endothelial progenitor cell (EPC) can differentiate to endothelial cell and promote angiogenesis, but its role in endothelial damage in GVHD is unclear.

Methods: In this study, we intend to assess whether EPC infusion promotes the repair of endothelial injury in GVHD mouse model.

PEDF reduces malignant cells proliferation and inhibits the progression of myelofibrosis in myeloproliferative neoplasms.

Pigment epithelial-derived factor (PEDF) exerts a broad spectrum of activities and has been implicated in diverse biological processes and a variety of diseases. However, the role of PEDF in myeloproliferative neoplasms (MPN) remains unknown. In this study, we found that PEDF expression was down-regulated in MPN patients and MPL-transuduced mice.

Dimethyl fumarate inhibits antibody-induced platelet destruction in immune thrombocytopenia mouse.

Background: Immune thrombocytopenia (ITP) is an autoimmune disease characterized as a low platelet count resulting from immune-mediated platelet destruction. Dimethyl fumarate (DMF) is widely applied for the treatment of several autoimmune diseases with immunosuppressive effect. However, whether it ameliorates ITP is unclear.

Nelfinavir restricts A549 cell growth by inhibiting STAT3 signaling.

Objective: To investigate the anticancer effect of nelfinavir (NFV) on human A549 cells.

Methods: The inhibitory effects of NFV on the proliferation of human A549 cells were assessed using a MTT assay. Apoptotic cells were observed by fluorescence microscopy following Hoechst 33342 staining.

Attention-Guided Deep Neural Network With Multi-Scale Feature Fusion for Liver Vessel Segmentation.

Liver vessel segmentation is fast becoming a key instrument in the diagnosis and surgical planning of liver diseases. In clinical practice, liver vessels are normally manual annotated by clinicians on each slice of CT images, which is extremely laborious. Several deep learning methods exist for liver vessel segmentation, however, promoting the performance of segmentation remains a major challenge due to the large variations and complex structure of liver vessels.

AI-assisted CT imaging analysis for COVID-19 screening: Building and deploying a medical AI system.

The sudden outbreak of novel coronavirus 2019 (COVID-19) increased the diagnostic burden of radiologists. In the time of an epidemic crisis, we hope artificial intelligence (AI) to reduce physician workload in regions with the outbreak, and improve the diagnosis accuracy for physicians before they could acquire enough experience with the new disease. In this paper, we present our experience in building and deploying an AI system that automatically analyzes CT images and provides the probability of infection to rapidly detect COVID-19 pneumonia.

Understanding the Morphology of High-Performance Solar Cells Based on a Low-Cost Polymer Donor.

A low-cost and high-performance bulk heterojunction (BHJ) solar cell comprising an emerging polymer donor, poly[(thiophene)--(6,7-difluoro-2-(2-hexyldecyloxy)quinoxaline)] (PTQ10), shows an efficiency of 12.7%. To improve the performance of the solar cells, a better understanding of the structure-property relationships of the PTQ10-based devices is crucial.

Preparation of the Auricularia auricular polysaccharides simulated hydrolysates and their hypoglycaemic effect.

The anti-diabetic effect of the Auricularia auricular polysaccharides simulated hydrolysates (APSHs) obtained from the dried fruiting body of Auricularia auricular was studied in this paper. The APSHs were administered intragastrically (i.g.

Gold nanoparticles coated with polysarcosine brushes to enhance their colloidal stability and circulation time in vivo.

Polysarcosine (PS), a non-ionic hydrophilic polypeptoid whose structure is similar to polypeptides, bearing repeating units of natural α-amino acid, has been used to stabilize gold nanoparticles (AuNPs) due to its excellent hydrophilicity and biocompatibility. Disulfide functionalized polysarcosines with different molecular weight were synthesized and used to cap AuNPs by traditional ligand exchange. The grafting of PS on AuNPs was evidenced by Fourier transform infrared (FTIR) spectroscopy and the alternation of surface zeta potential.