Publications by authors named "Zhengqi Guan"
Article Synopsis
- - The study investigated the use of a TIGIT-targeted PET tracer, [F]TTDP, to evaluate its potential in predicting how well non-small cell lung cancer (NSCLC) patients respond to immunotherapy based on TIGIT expression in tumor-infiltrating lymphocytes.
- - Researchers demonstrated that [F]TTDP specifically binds to both murine and human TIGIT and established the platform's effectiveness through PET imaging on mouse models that mirrored human NSCLC, showing high sensitivity (83.33%) and perfect specificity (100%) in predicting treatment responses.
- - The findings suggest that combining [F]TTDP with humanized immune system models offers a novel approach for better diagnosis and treatment predictions in cancer therapy,
Precision medicine is playing a pivotal role in strategies of cancer therapy. Unlike conventional one-size-fits-all chemotherapy or radiotherapy modalities, precision medicine could customize an individual treatment plan for cancer patients to acquire superior efficacy, while minimizing side effects. Precision medicine in cancer therapy relies on precise and timely tumor biological information.
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