A Multifunctional Bioadhesive for Bone Augmentation: Tissue Integration Combined with Antioxidant and Antibacterial Effects.

Guided bone regeneration (GBR) is a widely used clinical method for bone augmentation that features a barrier membrane that prevents soft tissue interference with osteogenesis. However, the most used collagen membranes and bone granules often struggle to maintain a stable bone formation space and create a microenvironment conducive to bone regeneration. In this study, a multifunctional bioadhesive (nSF@TA) is obtained from the reaction between nanofiber fibroin (nSF) and tannic acid (TA), which exhibits excellent wet adhesion properties on various substances and maintains a stable osteogenic space through tissue integration.

A self-activating electron transfer antibacterial strategy: CoO/TiO P-N heterojunctions combined with photothermal therapy.

Implant-associated infections are significant impediments to successful surgical outcomes, often resulting from persistent bacterial contamination. It has been hypothesized that bacteria can transfer electrons to semiconductors with comparable potential to the biological redox potential (BRP). Building on this concept, we developed an antibiotic-free bactericidal system, CoO/TiO-Ti, capable of achieving real-time and sustainable bactericidal effects.

A Biomimetic Nanogenerator to Enhance Bone Regeneration by Restoring Electric Microenvironments.

Piezoelectric materials have received increasing attention in bone regeneration due to their prominent role in bioelectricity in bone homeostasis. This study aimed to develop bioactive barium titanate-chitosan-graphene oxide piezoelectric nanoparticles (BCG-NPs) to improve biocompatibility and stimulate bone repair. Butterfly loops, hysteresis loops, and microcurrent studies on BCG-NPs confirmed their good piezoelectric properties.