In Utero Exposure to Fine Particulate Matter Causes Hypertension Due to Impaired Renal Dopamine D1 Receptor in Offspring.

Background/aims: Adverse environment in utero can modulate adult phenotypes including blood pressure. Fine particulate matter (PM2.5) exposure in utero causes hypertension in the offspring, but the exact mechanisms are not clear.

Long-Term Exposure of Fine Particulate Matter Causes Hypertension by Impaired Renal D Receptor-Mediated Sodium Excretion via Upregulation of G-Protein-Coupled Receptor Kinase Type 4 Expression in Sprague-Dawley Rats.

Background: Epidemiological evidence supports an important association between air pollution exposure and hypertension. However, the mechanisms are not clear.

Methods And Results: Our present study found that long-term exposure to fine particulate matter (PM) causes hypertension and impairs renal sodium excretion, which might be ascribed to lower D receptor expression and higher D receptor phosphorylation, accompanied with a higher G-protein-coupled receptor kinase type 4 (GRK4) expression.