Differences in gray matter atrophy and functional connectivity between motor subtypes of Parkinson's disease.

Parkinson's disease (PD) patients with postural gait abnormalities exhibit poorer motor function scores, more severe non-motor symptoms, faster cognitive function deterioration, and a less favorable response to drugs and surgery compared to PD patients with tremor. This discrepancy is believed to be associated with more pronounced gray matter atrophy and abnormal functional connectivity. To investigate the distinctive pathological mechanisms between PD subtypes, we examined gray matter volume (GMV) and functional connectivity in patients with Parkinson's disease presenting with postural instability/gait difficulty (PD-PIGD), patients with tremor-dominant Parkinson's disease (PD-TD), and healthy controls.

Abnormal cortical atrophy and functional connectivity are associated with depression in Parkinson's disease.

Objective: This study aimed to investigate the association of altered cortical thickness and functional connectivity (FC) with depression in Parkinson's disease (PD).

Materials And Methods: A total of 26 non-depressed PD patients (PD-ND), 30 PD patients with minor depression (PD-MnD), 32 PD patients with major depression (PD-MDD), and 30 healthy controls (HC) were enrolled. Differences in cortical thickness among the four groups were assessed, and the results were used to analyze FC differences in regions of cortical atrophy.

In situ modification of cobalt on MXene/TiO as composite photocatalyst for efficient nitrogen fixation.

Modulation of the binding of the reactant or product species with catalysts is an effective approach to optimize the photocatalytic activity. Herein, we explored the relationship between the binding of reactant (N) and product (NH) with catalyst and the photocatalytic nitrogen fixation activity. The surface reactivity of nitrogen with water was tuned by introducing Co into the MXene@TiO catalysts, which the TiO nanoparticle derived from the in-situ growth on the surface of MXene nanosheets.

MOF-Derived CoO@NC with Core-Shell Structures for N Electrochemical Reduction under Ambient Conditions.

We report the development of MOF-derived nitrogen-doped carbon/CoO nanocomposites (CoO@NCs) with core-shell structures as an efficient electrocatalyst for the artificial nitrogen fixation at room temperature and atmospheric pressure in 0.05 M HSO. It exhibits a high NH yield of 42.