SlTDF1: A key regulator of tapetum degradation and pollen development in tomato.

Pollen formation and development during the life cycle of flowering plant are crucial for maintaining reproductive and genetic diversity. In this study, an R2R3MYB family transcription factor, SlTDF1 (SlMYB35), was predominantly expressed in stamens. Repressed expression of SlTDF1 results in a delay in the degradation of the anther tapetum in tomatoes, which in turn leads to the formation of abnormal pollen, including a reduction in the number of single-fruit seeds and fertility when compared to wild-type plants.

Genome-Wide Evolutionary Characterization and Expression Analysis of Major Latex Protein (MLP) Family Genes in Tomato.

Major latex proteins (MLPs) play a key role in plant response to abiotic and biotic stresses. However, little is known about this gene family in tomatoes (). In this paper, we perform a genome-wide evolutionary characterization and gene expression analysis of the MLP family in tomatoes.

Better effect of intrapleural perfusion with hyperthermic chemotherapy by video-assisted thoracoscopic surgery for malignant pleural effusion treatment compared to normothermic chemoperfusion of the pleural cavity.

Objective: The aim of this study was to assess the efficacy and safety of intrapleural perfusion with hyperthermic chemotherapy (IPHC) in treating malignant pleural effusion (MPE) compared to normothermic chemoperfusion of the pleural cavity (NCPC), and to investigate the better treatment to control MPE.

Methods: Malignant pleural effusion patients were enrolled in the study and treated with NCPC or IPHC under video-assisted thoracoscopic surgery (VATS). The chest drainage duration, clinical characteristics, and recurrence time of pleural effusion of patients were collected for statistical analysis.

A Prognostic 14-Gene Expression Signature for Lung Adenocarcinoma: A Study Based on TCGA Data Mining.

Background: Lung adenocarcinoma (LUAD), a major and fatal subtype of lung cancer, caused lots of mortalities and showed different outcomes in prognosis. This study was to assess key genes and to develop a prognostic signature for the patient therapy with LUAD.

Method: RNA expression profile and clinical data from 522 LUAD patients were accessed and downloaded from the Cancer Genome Atlas (TCGA) database.

MME-YOLO: Multi-Sensor Multi-Level Enhanced YOLO for Robust Vehicle Detection in Traffic Surveillance.

As an effective means of solving collision problems caused by the limited perspective on board, the cooperative roadside system is gaining popularity. To improve the vehicle detection abilities in such online safety systems, in this paper, we propose a novel multi-sensor multi-level enhanced convolutional network model, called multi-sensor multi-level enhanced convolutional network architecture (MME-YOLO), with consideration of hybrid realistic scene of scales, illumination, and occlusion. MME-YOLO consists of two tightly coupled structures, i.

Three new bioactive flavonoid glycosides from Viscum album.

Two new flavonoid glycosides, named viscumneoside XII (1), and viscumneoside XIII (2); a new dihydrogen flavonoid glycoside product named viscumneoside XIV (3), were isolated from the aerial part of Viscum album, along with seven known compounds (4-10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory activities against C6, A549 and MDA-MB-231 (the inhibition rate arrived about 50%, 70% and 74% respectively with IC ≤ 60.

Two symmetrical unsaturated acids isolated from Viscum album.

In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 - 11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activity against xanthine oxidase (XOD) and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydroxyl (DPPH), with the IC of 1.

The Histologic Classifications of Lung Adenocarcinomas Are Discriminable by Unique Lineage Backgrounds.

Objectives: Lung adenocarcinomas are a heterogeneous set of diseases with distinct genetic and histologic characteristics. Besides the discovery of oncogenic mutations and introduction of the histologic classifications (2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society and 2015 WHO), increasing evidence has linked this intertumor heterogeneity to the lung lineage-specific pathways and lineage genes. Therefore, in this study, we assessed the gene expression of identified lung lineage genes to study their role in distinguishing lung adenocarcinoma diversities.

Oncogenic mutations are associated with histological subtypes but do not have an independent prognostic value in lung adenocarcinoma.

Lung adenocarcinomas have diverse genetic and morphological backgrounds and are usually classified according to their distinct oncogenic mutations (or so-called driver mutations) and histological subtypes (the de novo classification proposed by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society [IASLC/ATS/ERS]). Although both these classifications are essential for personalized treatment, their integrated clinical effect remains unclear. Therefore, we analyzed 981 lung adenocarcinomas to detect the potential correlation and combined effect of oncogenic mutations and histological subtype on prognosis.

Increases in the risk of cognitive impairment and alterations of cerebral β-amyloid metabolism in mouse model of heart failure.

Epidemiological and clinico-pathological studies indicate a causal relationship between heart disease and Alzheimer's disease (AD). To learn whether heart disease causes an onset of AD, mice with myocardial infarction (MI) and congestive heart failure (HF) were used to test neuropsychiatric and cognitive behaviors as well as for measurements of AD related protein markers. To this end, adult mice were subjected to ligation of left anterior descending artery (LAD) and about two weeks later high-frequency echocardiography was performed to exam the resulting cardiac structure and function.

Enhanced thermoelectric properties of Bi₀.₅Sb₁.₅Te₃ films by chemical vapor transport process.

Bi₀.₅Sb₁.₅Te₃ films were prepared by a novel chemical vapor transport process through delicate controlling the temperature of the substrate and vapor source.

[The effect of hyperbaric oxygen therapy to different degree of hearing loss and types of threshold curve in sudden deafness patients].

Objective: To investigate the effect of hyperbaric oxygen therapy to different degrees of hearing loss and different types of threshold curve in sudden deafness patients, and establish a personalized therapy, so as to promote clinical effect to sudden deafness.

Method: One hundred and twenty cases were divided into two groups respectively (each group 60 cases). Drug treatment had been used in group A for two weeks.

Top-down fabrication of nano-scaled Bi2Se(0.3)Te(2.7) associated by electrochemical Li intercalation.

A convenient top-down method for preparation of Bi(2)Se(0.3)Te(2.7) crystalline nano-particles has been demonstrated.

Synthesis and characterization of nanostructured bismuth selenide thin films.

Nanostructured bismuth selenide thin films have been successfully fabricated on a silicon substrate at low temperature by rational design of the precursor solution. Bi(2)Se(3) thin films were constructed of coalesced lamella in the thickness of 50-80 nm. The nucleation and growth process of Bi(2)Se(3) thin films, as well as the influence of solution chemistry on the film structure were investigated in detail.

Controllable synthesis and electrochemical hydrogen storage properties of Bi2Se3 architectural structures.

Two kinds of Bi2Se3 nanostructures, 3D rose-like hierarchitectures and monodisperse nanospheres, have been synthesized through adjusting the supersaturation of the precursor solution. Noticeable hydrogen storage capacity, amounting to 185 mA h g-1, has been found for the 3D rose-like hierarchitectures, which arises from the special micro/nano-hierarchitectures with highly crystallized flake-substructures.

[Choice of treatment plan and operation time on pediatric chronic sinusitis].

Objective: To explore the curative effect of pediatric chronic sinusitis and analyze its relative factors, so that the best treatment plan and operation time can be choose.

Method: Two hundred and twenty cases of pediatric chronic sinusitis were divided into 4 groups: group A with only simple chronic sinusitis, group B accompanied adenoid hypertrophy. Among group B, group B1 with no nasal cavity structural abnormalities but group B2 on the contrary.

[The value of cyclooxygenase-2 to predict the effect of radiotherapy in nasopharyngeal carcinoma].

Objective: To investigate the relation between the expression of COX-2 protein and the effect of radiotherapy, estimate the value of COX-2 in predicting the effect of radiotherapy in patients with nasopharyngeal carcinoma,provide theoretical basement for establishing characteristic project of treatment and raising curative effect and life quantity.

Method: The expression of COX-2 protein was examined in 30 radiosensitive and 30 radioresistant poorly differentiated NPC by immunohistochemical staining (SP method) before radiotherapy. The relation between the expression of COX-2 and the effect of radiotherapy was analyzed.

[Evidence-based treatment of secretory otitis media in patients with nasopharyngeal carcinoma after radiotherapy].

Objective: According to the principle of Evidence-Based Medicine (EBM), to analyse the cause of SOM in patients with nasopharyngeal carcinoma (NPC) after radiotherapy and to explore the effective treatment methods of SOM in patients with NPC after radiotherapy.

Method: One hundred and six cases (112 ears) of SOM in patients with NPC after radiotherapy were treated with comprehensive management,e. g application of general and local antibiotics,nerves nutrition medicine, blood vessel dilating drugs and hormone, reinforced clearance of nasal cavities and nasopharynx and treatment of the disease of nasal cavities and sinuses, in addition to inserting catheter into the tympanum and intratympanic application of medicine through the eustachian tube.

[Comparison of Epstein-Barr virus in nasopharynx tissue and desquamatine cell for diagnosis of nasopharyngeal carcinoma].

Objective: To develop a method for rapid screening and primary diagnosis of the nasopharyngeal carcinoma (NPC).

Method: We detected the Epstein Barr virus (EBV) DNA from nasopharynx tissue and desquamative cells in 144 suspicious NPC patients using polymerase chain reaction (PCR). The results were compared with the pathologic diagnosis.

[The features of auditory brainstem response in patients with obstructive sleep apnea-hypopnea syndrome].

Objective: To investigate the effects and causes of obstructive sleep apnea-hypopnea syndrome (OSAHS) on auditory pathway, the changes of auditory brainstem response (ABR) were analyzed.

Method: With the use of polysomnography,72 snorers were examined and divided into OSAHS and non- OSAHS groups. These two groups patients and a group of normal person were underwent ABR measuring.

[Implantation of complex tissue flap for atrophic rhinitis].

Objective: To improve the treatment effect of atrophic rhinitis.

Method: Twenty-one cases (thirty-one sides) of atrophic rhinitis were treated by implantation of complex tissue flap to narrow the nasal cavity.

Result: Short-term effective treatment results were 100% (21/21), long-term effective treatment results were 90.

[Association between the shape alteration of pharyngeal ostium of eustachian tube and secretory otitis media].

Objective: To investigate the association between the shape alteration of pharyngeal ostium of eustachian tube and secretory otitis media (SOM).

Method: Two hundred and twelve pharyngeal ostiums of eustachian tube were observed by using rhinopharyngoscope and divided into two groups: the contrast's and the secretory otitis media's, and all the shape of pharyngeal ostium of eustachian tube were divided into triangular type, cravice type, elliptical type and bell type.

Result: The shape of pharyngeal ostium of eustachian tube are remarkablely difference with the normal group and the diseased group.

[Relationship between adenoids hypertrophy and secretory otitis media].

Objective: To investigae the cause of secretory otitis media resulting from adenoids hypertrophy and the relationship between adenoids hypertrophy and secretory otitis media.

Method: According to the grades of adenoids hypertrophy, 140 children were divided into two groups: the group of middle-grade and the group of pathological hypertrophy. The effect about the degree of adenoids hypertrophy resulted in the descendent of middle ear function and the difference of incidence of secretory otitis media were analyzed.

[Selection of operative approaches for rhinosinusal malignant tumor involving in the anterior skull base and exploration for reconstruction].

Objective: To investigate operative approaches and techniques of reconstruction for rhinosinusal malignant tumors involving in the anterior skull base.

Method: In a retrospective study, clinical data of 22 patients treated surgically in our department from 1988 to 2002 were analysed. Lateral rhinotomy was carried out in 8 patients and ampliative rhinotomy in 4 patients; in 10 patients craniofacial operation was performed.