Repurposing CD5789 as an Antimicrobial Agent Against MRSA and Its High Resistant Phonotypes.

Methicillin-resistant Staphylococcus aureus (MRSA) poses a great threat to human health, and the formation of biofilm and persister cells make the situation even worse. Drug repurposing is an effective way to solve this problem by shortening the drug development times and reducing the research costs. In this study, CD5789 (trifarotene), a fourth-generation retinoid to be approved by the FDA in 2019 for the topical acne vulgaris regimens, was exhibited antimicrobial activity against MRSA type strains and its clinical isolates with the minimal concentration (MIC) of 2-4 μg/mL and 4-16 μg/mL, respectively, in a dose-dependent manner.

Antiplanktonic and antibiofilm effects of two synthetic antimicrobial peptides against .

Objectives: is one of the most common Gram-positive cocci in nosocomial infection, which could adhere to the surface of medical apparatus and causes biofilm-related infections. In the present study, we aim to explore the antimicrobial effects of GH12 and SAAP-148 against

Methods: Micro-dilution methods were used to detect the minimal inhibitory/bactericidal concentration of peptides on . Biofilm formation positive type strain was used to determine the antibiofilm effects of the peptides.