Publications by authors named "Zhengkun Wu"

Article Synopsis
  • Luteolin is a natural flavonoid found in various plants and has properties that lower uric acid and act as an antioxidant, but its exact mechanism for treating hyperuricemia nephropathy (HN) is not completely understood.
  • This study investigates the effects of luteolin in HN using mouse models and cell cultures, finding that it helps protect kidney tissue and improve renal functions by reducing specific harmful proteins and activating beneficial pathways.
  • The results indicate that luteolin aids in kidney injury recovery by enhancing urate excretion and antioxidant activity while also inhibiting xanthine oxidase in the liver, suggesting it could be a potential treatment for HN.
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Transition metal oxide semiconductors have great potential for use in H sensors, but in recent years, the strange phenomena about gas-sensitive performance associated with their special properties have been more widely discussed in research. In some cases, the resistance of transition metal oxide gas sensors will emerge with some changes contrary to their intrinsic semiconductor characteristics, especially in gas sensor research of WO. Based on the hydrothermal synthesis of WO, our work focuses on the abnormal change of tungsten oxide resistance to different gases at low temperature (80-200 °C) and high temperature (above 200 °C).

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Oxygen vacancies (V) in metal oxide semiconductors play an important role in improving gas-sensing performance of chemiresistive gas sensors. Nonetheless, there is still a lack of clear understanding of the inherent mechanism of the influence of oxygen vacancies on gas sensing due to generally focusing on the concentration of V. Herein, oxygen vacancies were rationally modulated in WO nanoflower structures via an annealing process, resulting in a transformation of V from neutral (V) to a doubly ionized (V) state.

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Introduction: Although flavonoid compounds exhibit various pharmacological activities, their clinical applications are restricted by low oral bioavailability owing to their poor solubility. Nanocrystals (NCs) represent an excellent strategy for enhancing the oral bioavailability of flavonoids. Hydroxyethyl starch (HES), a biomaterial compound used as a plasma expander, could be an ideal stabilizer material for preparing flavonoid NCs.

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Background: Tinnitus diagnosis poses a challenge in otolaryngology owing to an extremely complex pathogenesis, lack of effective objectification methods, and factor-affected diagnosis. There is currently a lack of explainable auxiliary diagnostic tools for tinnitus in clinical practice.

Objective: This study aims to develop a diagnostic model using an explainable artificial intelligence (AI) method to address the issue of low accuracy in tinnitus diagnosis.

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Hydrogen can be regarded as an ideal type of secondary energy considering its potential for achieving renewable and sustainable development due to water being its sole combustion product and its possible production by solar energy-based water electrolysis. Monitoring the presence and concentration of hydrogen during production, transportation, and application requires a hydrogen gas sensor with high response, high selectivity, and fast response and recovery times. In an attempt to meet these requirements, NiO and PdO are used in the co-doping of InO nanotubes by subsequent electrospinning and impregnation under UV irradiation.

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Background: Pancreatic cancer is a fatal disease with a very poor prognosis due to its characteristic insidious symptoms, early metastasis, and chemoresistance. Circular RNAs (circRNAs) are involved in the development of pancreatic cancer.

Aim: Hence, the aim of this study is to elucidate the mechanism of circRNA_000864 in regulating BTG2 expression in pancreatic cancer by binding to miR-361-3p.

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Polymer-based micromolding has been proposed as an alternative to SU-8 micromolding for microfluidic chip fabrication. However, surface defects such as milling marks may result in rough microchannels and micromolds, limiting microfluidic device performance. Therefore, we use chemical and mechanical methods for polishing polymer microchannels and micromolds.

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