Publications by authors named "Zhengjun Wu"

Lysosomal biothiols play critical roles in numerous cellular processes and diseases. Researching an effective method for real-time labeling biothiols in lysosomes is of great significance and urgency, as it could provide essential information for the diagnosis of relevant diseases. In this study, we developed a lysosome-targeted fluorescent probe (LY-DCM-P) with a large Stokes shift of 150 nm for the sensitive and selective detection of biothiols and .

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Introduction: This study investigated the association between the fetal-type posterior cerebral artery (FTP) and hypertensive thalamic hemorrhage (HTH).

Method: Patients with hypertension who met the admission criteria between January 2020 and August 2022 were retrospectively analyzed and divided into the HTH and non-HTH groups based on the presence or absence of thalamic hemorrhage, respectively. In addition to whether the variable was an FTP, other variables with unbalanced distributions between the two groups were used as matching factors for 1:1 propensity score matching, and other variables that were not used as matching factors were used as covariates for conditional logistic regression.

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In this study, a new near-infrared (NIR) fluorescent turn-on probe featuring a large Stokes shift (198 nm) was developed for the detection of biothiols. The probe was based on a dicyanoisophorone derivative serving as the fluorophore and a 2,4-dinitrobenzenesulfonyl (DNBS) group functioning as both a recognition site and a fluorescence quencher. In the absence of biothiols, the fluorescence of the probe was low due to the photoinduced electron transfer (PET) effect between the fluorophore and DNBS.

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Developing NIR-IIb luminescence probes with rapid visualization and a high penetration depth is essential for diabetes research. Combining a sensitizing switch with lanthanide-doped nanoparticles (LnNPs) has been employed to fabricate the NIR-IIb probes. However, these probes mainly adopt heptamethine cyanine dye as the antenna, and the NIR-IIb signal is activated by inhibiting the photoinduced electron transfer (PET) of the dye.

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In managed care settings, primates are susceptible to a variety of health complications. A comprehensive understanding of the causes of mortality and their association with management practices is essential for enhancing the welfare of managed care populations such as François' langurs (). However, literature addressing prevalent diseases or causes of death in such settings remains limited among François' langurs in managed care.

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The complex sample matrix poses significant challenges in accurately detecting heavy metals. In view of its superior performance for the biological adsorption of heavy metals, probiotic bacteria can be explored for functional unit to eliminate matrix interference. Herein, Lactobacillus rhamnosus (LGG) demonstrates a remarkable tolerance and can adsorb up to 300 μM of Hg, following the Freundlich isotherm model with the correlation coefficient (R) value of 0.

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Biothiols, including cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), play distinct yet crucial roles in various mitochondrial physiological activities. However, due to their similar chemical structures, distinguishing and detecting Cys/Hcy/GSH poses a considerable challenge. In this study, we developed a dual-channel, mitochondrial-targeted fluorescent probe termed QX-NBD, designed specifically for discriminating Cys/Hcy from GSH.

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Metabolic syndrome (MetS) is a global epidemic complex and will cause serious metabolic comorbidities without treatment. A prevention strategy for MetS development has been proposed to modulate gut microbiota by probiotic administration to improve intestinal dysbiosis and benefit the host. Lacticaseibacillus casei LC2W has exhibited positive effects in preventing colitis and anti-hypertension in vivo.

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Article Synopsis
  • - Adult T-cell leukemia/lymphoma (ATLL) is a serious cancer with a grim outlook, and limited data exists on its effects specifically in the Chinese population; this study looked at 115 patients treated in China over more than a decade.
  • - Key genetic mutations related to T-cell receptor signaling were found in patients, with most of them receiving chemotherapy; the study showed that EPOCH/CHOEP chemotherapy resulted in an 80.6% response rate, while the overall survival rates varied significantly based on treatment type.
  • - Factors like lymphadenopathy, the use of EPOCH/CHOEP chemotherapy, and hematopoietic stem cell transplantation were identified as important in improving patient outcomes, signaling that these treatments
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As an invasive alien animal, Pomacea canaliculata poses a great danger to the ecology and human beings. Recently, there has been a gradual shift towards bio-friendly control. Based on the development of RNA interference and CRISPR technology as molecular regulatory techniques for pest control, it was determined if the knockout of genes related to sex differentiation in P.

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Background: Adverse reactions induced by isoosmolar contrast medium (iodixanol) are mostly mild, with rashes and headaches being the most common. Although anaphylactic shock has been reported, no related incidents have been documented on cerebral angiography.

Objective: This article reports a serious case of anaphylactic shock possibly induced by iodixanol and provides an overview of the case report.

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(Fabaceae) species are rich in metabolites and widely used in medicine. Research on the chloroplast genome of is important for understanding its phylogenetics, biogeography, genetic diversity, species identification, and medicinal properties. In this study, comparative genomics and phylogenomics of were analyzed based on the chloroplast genome.

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This study aimed to analyse the characteristics and treatment outcomes of adult patients with acute lymphoblastic leukaemia (ALL) and construct nomogram predictive models for prognosis prediction. Between January 2017 and June 2022, 462 adult patients with ALL were included in this retrospective analysis. Patients' ages ranged from 14 to 84 years.

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An exopolysaccharide, designated F1, was purified from the fermented milk by Lacticaseibacillus rhamnosus strain B6 (CGMCC No. 13310). F1, with the weight average molecular weight of 1.

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This study aimed to examine the characteristics and treatment outcomes of patients with TP53-mutant acute myeloid leukaemia (AML) and to explore potential prognostic factors. This retrospective analysis included 130 patients diagnosed with TP53-mutant AML at the Fujian Medical University Union Hospital between January 2016 and June 2023. Patients' ages ranged from 17 to 80 years, with a median age of 59 years.

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The metabolite and peptide profiles of fresh cheese fermented by three novel probiotics, B6, B44 and KF7, were investigated using LC-MS/MS-based metabolomics and peptidomics. The multivariate analysis revealed significant differences in metabolite composition between the probiotic fresh cheese and the control sample. The differential metabolites were primarily lipids and lipid-like molecules and organic oxygen compounds, which were associated with fatty acid and carbohydrate-related pathways.

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The aim of this study was to examine the characteristics and prognosis of patients with myelodysplastic syndrome (MDS) accompanied by abnormalities and explore potential prognostic factors and treatment responses. This retrospective analysis included 95 patients with MDS and abnormalities and 173 patients with MDS without abnormalities at the Fujian Medical University Union Hospital between January 2016 and June 2023. Among patients with abnormalities, 26 (27.

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The gut microbiota plays an essential role in maintaining the health and fitness of the host organism. As a critical environmental variable, temperature exerts significant effects on animal survival and reproduction. Elevated temperatures can influence the composition and function of the animal gut microbiota, which may have potentially detrimental effects on the host.

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Strain BD7642 was isolated from Chinese pickled potherb mustard ( Coss.) purchased from a local market in Shanghai, PR China. A polyphasic approach, including 16S rRNA gene sequence, housekeeping gene, average nucleotide identity (ANI), digital DNA-DNA hybridization (dDDH), G+C content and phenotypic analyses, was employed to characterize strain BD7642.

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Red swamp crayfish, Procambarus clarkii, is a globally invasive species, which has caused great damage to biodiversity, agriculture, and fishing. Therefore, the development of effective management methods, such as pheromone control, is necessary for biological control and biodiversity protection. However, the components of P.

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Purpose: Most patients with acute lymphoblastic leukemia (ALL) are treated with chemotherapy as primary care. Although the treatment response is usually positive, resistance and relapse often occur via unknown mechanisms. The purpose of this study was to identify factors associated with chemotherapy resistance in ALL.

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In this study, based on morphological and molecular data, a new bush frog species is described from Yunnan, China. Eleven samples of . were collected from Malipo County, southeastern Yunnan.

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Article Synopsis
  • - Heavy metal pollution poses significant health risks as it enters the body through the food chain and environmental exposure, potentially causing serious diseases by disrupting gut function and harming various organs.
  • - Probiotics, specifically lactic acid bacteria (LAB), can help detoxify heavy metals due to their safety and effectiveness, with exopolysaccharides (EPS) from LAB playing a crucial role in absorbing these toxins.
  • - The study highlights that EPS-producing LAB are more efficient at detoxifying heavy metals compared to non-EPS producers, but further research is needed to clarify the effects of heavy metal accumulation on nearby mammalian tissues and their excretion process.
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EPS53, a homogeneous exopolysaccharide (EPS) was isolated from Streptococcus thermophiles XJ53 fermented in skimmed milk via anion exchange column chromatography. The relative molecular weight of EPS53 was above 6.7 × 10 g/mol; its repeating structural unit of EPS53 consisted of β-T-Galp, β-1,3-Galf, α-1,3-Glcp and β-1,3,6-Glcp residues in a molar ratio of 1:1:1:1, with β-T-Galp attached to the O-6 position of β-1,3,6-Glcp,identical to the EPS produced from S.

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