Publications by authors named "Zhengjuan Wu"
Abnormal Weakening of DNA Methylation around the Gene Promoter in Temporal Lobe Epilepsy.
J Integr Neurosci
September 2024
Article Synopsis
- The study investigates DNA methylation patterns of specific solute carrier genes linked to epilepsy in patients with temporal lobe epilepsy (TLE) and healthy controls.
- Results show that TLE patients have significantly lower DNA methylation rates compared to controls, which may help in developing predictive models for TLE.
- The findings indicate that reduced methylation could potentially lead to increased gene expression in TLE, but further research is needed to clarify the mechanisms involved.
Article Synopsis
- * The review discusses how AD's classical pathologies, such as amyloid-beta plaques and tau, might lead to epilepsy, and emphasizes the role of neurotransmitter imbalances in both conditions, especially regarding the age at which these diseases manifest.
- * The article stresses the need for careful medication management due to cognitive side effects of antiepileptic drugs, while also exploring possible treatments like lamotrigine, levetiracetam, and emerging options such as the ketogenic diet and cannabidiol, suggesting they deserve further research for better patient