Publications by authors named "Zhengju Li"
Article Synopsis
- Mitochondria are essential for energy production in cells, and damage to them can lead to cellular decline and activate autophagy, a cellular cleanup process.
- * This review discusses how mitochondrial autophagy influences duodenal issues like mucosal barrier damage, inflammation, and disrupted signaling, offering insights into functional dyspepsia's causes.
- * It highlights the role of eosinophils and mast cells in triggering gastrointestinal hypersensitivity and motility disorders, and calls for further research on mitochondrial autophagy to enhance treatments for functional dyspepsia.
Liver fibrosis is a key pathological stage in the progression of chronic liver disease. If the disease is mistreated, it can further deteriorate into liver failure, which seriously affects the quality of life of patients and brings heavy medical costs. Hepatic stellate cell(HSC) activation triggers extracellular matrix(ECM) deposition, which plays an important driving role in liver fibrosis, and ferroptosis is an effective strategy to clear or reverse the activation of HSCs into a deactivated phenotype.
View Article and Find Full Text PDFA review of edible plant-derived natural compounds for the therapy of liver fibrosis.
Eur J Gastroenterol Hepatol
February 2023
Liver fibrosis has a high incidence worldwide and is the common pathological basis of many chronic liver diseases. Liver fibrosis is caused by the excessive deposition of extracellular matrix and concomitant collagen accumulation in livers and can lead to the development of liver cirrhosis and even liver cancer. A large number of studies have provided evidence that liver fibrosis can be blocked or even reversed by appropriate medical interventions.
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