Pan-cancer landscape of disulfidptosis across human tumors.

Objective: Disulfidptosis is a newly discovered disulfide stress-induced cell death form. Clinical significance and biological mechanisms of disulfidptosis in human cancers need to be further elucidated. Thus, this study was designed to characterize pan-cancer landscape of disulfidptosis across human tumors.

Synergetic Optimization of Upper and Lower Surfaces of the SnO Electron Transport Layer for High-Performance n-i-p Perovskite Solar Cells.

The SnO electron transport layer (ETL) has been recognized as one of the most effective protocols for achieving high-efficiency perovskite solar cells (PSCs). To date, most research has primarily focused on the modification of the upper surface of SnO ETL films. The lower surface of the SnO film, which directly influences the film formation of solution-processed SnO, is equally important but receives relatively less attention.

Presence of CoV-2 antibody in vitreous humor after Cov-2 infection.

Purpose: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease with largely unknown intraocular pathogenesis. Herein, we determined the presence of SARS-CoV-2-specific ribonucleic acid (RNA) and virus-associated antibodies in the vitreous humor of people who have recently recovered from SARS-CoV-2 infection.

Design: This cross-sectional study included 33 patients (33 eyes) who have recently recovered from SARS-CoV-2 infection.

Room Temperature Ionic Liquid Capping Layer for High Efficiency FAPbI Perovskite Solar Cells with Long-Term Stability.

Ionic liquid salts (ILs) are generally recognized as additives in perovskite precursor solutions to enhance the efficiency and stability of solar cells. However, the success of ILs incorporation as additives is highly dependent on the precursor formulation and perovskite crystallization process, posing challenges for industrial-scale implementation. In this study, a room-temperature spin-coated IL, n-butylamine acetate (BAAc), is identified as an ideal passivation agent for formamidinium lead iodide (FAPbI) films.

A 4.43 TΩ Z 0.0128 mm Cascaded Instrumentation Amplifier with Input-biased Pseudo Resistor for Implantable Brain Machine Interfaces.

A cascaded instrumentation amplifier (CaIA) with input-biased pseudo resistors (IBPR) is presented for implantable brain machine interfaces (BMI). The gain distribution of two-stage cascaded amplifiers, instead of a single-stage amplifier, helps to achieve an input impedance of 4.43TΩ at 100Hz, and maintain the small active area (0.

Fluorinated Graphene-Lewis-Base Polymer Composites as a Multifunctional Passivation Layer for High-Performance Perovskite Solar Cells.

Increasing the open-circuit voltage () stands as a critical strategy for further improving the efficiency of organic-inorganic halide perovskite solar cells (PSCs). Lewis basic polymers, such as polymethyl methacrylate (PMMA), are considered as an effective approach to reduce the nonradiative recombination at the perovskite surface and protect the photoactive layer against moisture. However, the insulating nature of PMMA inherently leads to increased series resistance in PSCs.

Integrated profiling uncovers prognostic, immunological, and pharmacogenomic features of ferroptosis in triple-negative breast cancer.

Objective: Ferroptosis is an iron-dependent type of regulated cell death triggered by the toxic buildup of lipid peroxides on cell membranes. Nonetheless, the implication of ferroptosis in triple-negative breast cancer (TNBC), which is the most aggressive subtype of breast carcinoma, remains unexplored.

Methods: Three TNBC cohorts-TCGA-TNBC, GSE58812, and METABRIC-were adopted.

Contribution of Tibetan Plateau ecosystems to local and remote precipitation through moisture recycling.

The ecosystems of the Tibetan Plateau (TP) provide multiple important ecosystem services that benefit both local populations and those beyond, such as through climate regulation services on precipitation for East Asia and China. However, the precipitation regulation service of the TP ecosystems for supplying moisture and maintaining precipitation is yet to be evaluated. In this study, we used the moisture recycling framework and a moisture tracking model to quantify the precipitation regulation services of TP ecosystems for their contribution to precipitation.

A Nontoxic NFM Solvent for High-Efficiency Perovskite Solar Cells with a Widened Processing Window.

With the steady industrialization process of the perovskite solar cells (PSCs), the toxicity of the used solvents has become a pivotal issue that needs to be addressed. Especially, the usage of ,-dimethylformamide (DMF) solvent would pose serious environmental and health concerns. Herein, we have reported a nontoxic solvent -formylmorpholine (NFM) to replace the toxic DMF and have achieved a higher PCE of 22.

Thermal Annealing-Free SnO for Fully Room-Temperature-Processed Perovskite Solar Cells.

The SnO electron transport layer (ETL) for perovskite solar cells (PSCs) has been recognized as one of the most reported protocols due to its processing convenience, high reproducibility, and excellence in device performance. To date, the thermal annealing (TA) process is still an essential step for a high-quality SnO ETL to reduce the surface trap density. This however could restrict its processing with high thermal energy input and set a barrier to the easiness of manufacturing such as processing under room-temperature conditions.

Double-Layer Solid Composite Electrolytes Enabling Improved Room-Temperature Cycling Performance for High-Voltage Lithium Metal Batteries.

The development of solid-state electrolytes (SSEs) for high energy density lithium metal batteries (LMBs) usually needs to take into account of the interfacial compatibility against lithium metal and the electrolyte stability suitable for a high-potential cathode. In this study, through a facile two-step coating process, novel double-layer solid composite electrolytes (SCEs) with Janus characteristics are customized for the high-voltage LMBs with improved room-temperature cycling performance. Among which, high-voltage resistant poly(vinylidene fluoride) (PVDF) is adopted here for the construction of an electrolyte layer facing the cathode, while the other layer against the lithium anode is composed of the polymer matrix of poly(ethylene oxide) (PEO) blended with PVDF to obtain a lithium metal-friendly interface.

Comprehensive Analysis of Ferroptosis-Related LncRNAs in Breast Cancer Patients Reveals Prognostic Value and Relationship With Tumor Immune Microenvironment.

Breast cancer (BC) is a heterogeneous malignant tumor, leading to the second major cause of female mortality. This study aimed to establish an in-depth relationship between ferroptosis-related LncRNA (FRlncRNA) and the prognosis as well as immune microenvironment of the patients with BC. We downloaded and integrated the gene expression data and the clinical information of the patients with BC from The Cancer Genome Atlas (TCGA) database.

Sodium butyrate alleviates cholesterol gallstones by regulating bile acid metabolism.

Cholesterol overloading and bile acid metabolic disorders play an important role in the onset of cholesterol gallstone (CGS). Short-chain fatty acids (SCFAs) can regulate bile acid metabolism by modulating the gut microbiota. However, the role and mechanism by which sodium butyrate (NaB) targets bile acids to attenuate CGS are still unknown.

A Safe Flexible Self-Powered Wristband System by Integrating Defective MnO Nanosheet-Based Zinc-Ion Batteries with Perovskite Solar Cells.

The booming market of portable and wearable electronics has aroused the requests for advanced flexible self-powered energy systems featuring both excellent performance and high safety. Herein, we report a safe, flexible, self-powered wristband system by integrating high-performance zinc-ion batteries (ZIBs) with perovskite solar cells (PSCs). ZIBs were first fabricated on the basis of a defective MnO nanosheet-grown carbon cloth (MnO@CC), which was obtained the simple lithium treatment of the MnO nanosheets to slightly expand the interlayer spacing and generate rich oxygen vacancies.

lncRNA FGD5‑AS1 promotes breast cancer progression by regulating the hsa‑miR‑195‑5p/NUAK2 axis.

Breast cancer is the second most prevalent cancer in women worldwide. Long non‑coding RNAs (lncRNAs) have been identified as important regulators of tumorigenesis and tumor metastasis. lncRNA FGD5‑AS1 has been previously reported as a carcinogenic gene, however its role in breast cancer has yet to be investigated.

Novel High-Sensitivity Racetrack Surface Plasmon Resonance Sensor Modified by Graphene.

In order to overcome the existing challenges presented by conventional sensors, including their large size, a complicated preparation process, and difficulties filling the sensing media, a novel high-sensitivity plasmonic resonator sensor which is composed of two graphene-modified straight waveguides, two metallic layers, and a racetrack nanodisk resonator is proposed in this study. The transmission characteristics, which were calculated by the finite element theory, were used to further analyze the sensing properties. The results of quantitative analysis show that the proposed plasmonic sensor generates two resonance peaks for the different incident wavelengths, and both resonance peaks can be tuned by temperature.

Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population.

Aim: To assess disease-specific circulating microRNAs (miRNAs) in non-alcoholic steatohepatitis (NASH) patients.

Methods: A total of 111 biopsy-proven non-alcoholic fatty liver disease (NAFLD) or chronic hepatitis B (CHB) patients and healthy controls from mainland China were enrolled to measure their serum levels of miR-122, -125b, -146b, -16, -21, -192, -27b and -34a. The correlations between serum miRNAs and histological features of NAFLD were determined.

Evaluating the Relationship Between Metabolic Syndrome and Liver Biopsy-Proven Non-Alcoholic Steatohepatitis in China: A Multicenter Cross-Sectional Study Design.

Introduction: Non-alcoholic steatohepatitis (NASH) is a serious form of non-alcoholic fatty liver disease (NAFLD) that can progress to advanced fibrosis, cirrhosis, and hepatocellular carcinoma. Differentiating between non-alcoholic fatty liver (NAFL) and NASH/advanced fibrosis is an important step in the management of NAFLD. Metabolic syndrome (MS) and its components are important risk factors for NAFLD, and NASH is thought to be the hepatic injury of MS.

Nucleotide oligomerization domain 2 contributes to the innate immune response in THCE cells stimulated by Aspergillus fumigatus conidia.

Aim: To investigate the expression of nucleotide oligomerization domain 2 (NOD2) in the immortalized human corneal epithelial cell line (THCE), and its role in the innate immune response triggered by inactive Aspergillus fumigatus (Af) conidia.

Methods: The normal THCE cells were investigated as controls. After incubation with inactive Af conidia for 0.

Impaired iNOS-sGC-cGMP signalling contributes to chronic hypoxic and hypercapnic pulmonary hypertension in rat.

Nitric oxide (NO) is an important vascular modulator in the development of pulmonary hypertension. NO exerts its regulatory effect mainly by activating soluble guanylate cyclase (sGC) to synthesize cyclic guanosine monophosphate (cGMP). Exposure to hypoxia causes pulmonary hypertension.

Phosphatidylinositol 3-kinase inhibitor suppresses inducible nitric oxide synthase expression in bronchiole epithelial cells in asthmatic rats.

Inducible nitric oxide synthase (iNOS) is known to produce nitric oxide (NO), which is a main contributor to asthmatic airway inflammation. Recent studies have shown that phosphatidylinositol 3-kinase (PI3K) is ubiquitously expressed in airway epithelial cells and its inhibition could relieve airway inflammation and hyperresponsiveness. This study aimed to explore the interaction of PI3K and NO signaling in allergic asthma.

Success rate and complications of endoscopic extraction of common bile duct stones over 2 cm in diameter.

Background: Clinically, common bile duct (CBD) stones >2 cm are difficult to remove by endoscopic retrograde cholangiopancreatography (ERCP). To evaluate this observation, the rates of successful clearance of CBD stones and complications were compared between ERCP extraction of CBD stones of >2 cm and <2 cm in diameter.

Methods: All patients who had undergone endoscopic extraction of CBD stones at the Endoscopy Center of Shanghai First People's Hospital from May 2004 to May 2008 were reviewed.