Effect of inflammatory factors on myocardial infarction.

Background: Cohort studies have increasingly shown associations between inflammatory markers and myocardial infarction (MI); however, the specific causal relationships between inflammatory markers and the development of MI remain unclear.

Methods And Results: By utilizing publicly accessible genome-wide association studies, we performed a two-sample Mendelian randomization (MR) analysis to explore the causal associations between inflammatory markers and myocardial infarction (MI). A random-effects inverse-variance weighted method was used to calculate effect estimates.

Lead Tolerance and Remediation Potential of Four Species in Lead-Contaminated Soil.

plants are low-growing shrubby bamboos with growth advantages, such as high biomass and strong resistance, and they are rich in germplasm resources in southern China. This study conducted soil lead (Pb) stress experiments on (Keng) McClure (LA), B.M.

Sasa argenteostriata - A potential plant for phytostabilization remediation of lead-zinc tailing-contaminated soil.

Phytoremediation is an effective way to remediate metal-contaminated soils. During phytoremediation, plants immobilize heavy metals through the roots to reduce the mobility, toxicity and dispersal of the metals, and the changes in the activity of the roots are often accompanied by changes in the rhizosphere ecosystems, in which rhizobacteria are essential components and interact with roots to maintain the stability of the rhizosphere ecosystem and improve soil health. In this study, the phytoremediation potential of Sasa argenteostriata (Regel) E.

Effects of Low-Light Environments on the Growth and Physiological and Biochemical Parameters of and Seasonal Variations in Leaf Active Substance Contents.

, characterized by its expansive leaves, low height, strong reproductive capacity, and abundant bioactive compounds, has extensive utility in the realms of food processing, the manufacturing of packaging materials, and the advancement of novel pharmaceuticals. Two light environments, CK (100% full light) and ST (50% full light), were established to explore the effects of low-light environments on the reproductive ability, morphological characteristics, photosynthetic properties, and leaf active substances of 14 species. The findings revealed that in comparison to the CK treatment, for 14 species of under the ST treatment, (1) the diameter, single leaf area, and leaf area index increased by 8.

Effects of Linpan nature therapy on health benefits in older women with and without hypertension.

Background: Nature therapy can significantly benefit the physiology and psychology of middle-aged and older people, but previous studies have focused on forest environments. The restoration potential of rural environments in urban fringe areas, which are more accessible to older people on a daily basis, has not been fully studied. This study assessed the effects of nature therapy on the physical and mental health of older women in a rural setting (locally known as Linpan) in the urban fringe area of Chengdu, China.

The role of miR1 and miR133a in new-onset atrial fibrillation after acute myocardial infarction.

Background: The development of new-onset atrial fibrillation (NOAF) after acute myocardial infarction (AMI) is a clinical complication that requires a better understanding of the causative risk factors. This study aimed to explore the risk factors and the expression and function of miR-1 and miR-133a in new atrial fibrillation after AMI.

Methods: We collected clinical data from 172 patients with AMI treated with emergency percutaneous coronary intervention (PCI) between October 2021 and October 2022.

A Suboptimal Optimizing Strategy for Velocity Vector Estimation in Single-Observer Passive Localization.

In a single-observer passive localization system, the velocity and position of the target are estimated simultaneously. However, this can lead to correlated errors and distortion of the estimated value, making independent estimation of the speed and position necessary. In this study, we introduce a novel optimization strategy, suboptimal estimation, for independently estimating the velocity vector in single-observer passive localization.

Effects of Simultaneous Application of Double Chelating Agents to Pb-Contaminated Soil on the Phytoremediation Efficiency of Q. H. Dai and the Soil Environment.

Recent studies have shown that the combined application of ethylenediaminetetraacetic acid (EDTA) and degradable chelating agents can enhance EDTA's affinity for heavy metals and reduce its toxicity, but the effect of this combination on the phytoremediation remains largely unknown. This study evaluated and compared the effects of EDTA, nitrilotriacetic acid (NTA), and glutamic acid-N,N-diacetic acid (GLDA) alone (E, N, G treatment), and in combination (EN and EG treatment), on the growth of dwarf bamboo ( Q. H.

Tolerance and Heavy Metal Accumulation Characteristics of (Regel) E.G. Camus under Zinc Single Stress and Combined Lead-Zinc Stress.

(Regel) E.G. Camus is a gramineous plant with the potential for phytoremediation.

Efficiency of heterogeneous chelating agents on the phytoremediation potential and growth of Sasa argenteostriata (Regel) E.G. Camus on Pb-contaminated soil.

Ethylenediaminetetraacetic acid (EDTA) is one of the most effective chelating agents for enhancing lead (Pb) accumulation in various plant organs. However, it has a higher risk of causing secondary pollution than other chelating agents. To reduce such environmental risks and increase remediation efficiency, EDTA can be combined with degradable chelating agents for use in phytoremediation, but there are few reports on the combination of EDTA and nitrilotriacetic acid (NTA).

Dynamic study of the lead (Pb) tolerance and accumulation characteristics of new dwarf bamboo in Pb-contaminated soil.

Dwarf bamboo is a woody plant with potential for use in the remediation of Pb-contaminated soil. Due to its clonal growth habit, there are two keys to its application for continuous soil Pb remediation: 1) its ability to form shoots and grow into new bamboo normally under Pb stress and 2) the Pb tolerance and accumulation characteristics of this new bamboo. Here, 5 species of dwarf bamboo were treated with 2 levels of soil Pb stress (0 and 1500 mg kg).

Effects of Variations in Color and Organ of Color Expression in Urban Ornamental Bamboo Landscapes on the Physiological and Psychological Responses of College Students.

Visual characteristics (e.g., the color and shape) of ornamental plants can significantly affect their beneficial influence on humans.

Biomass allocation strategies and Pb-enrichment characteristics of six dwarf bamboos under soil Pb stress.

Dwarf bamboos are clonal plants with potential applications in the remediation of heavy metal-polluted soils, although their pollution adaptation strategies are unknown. This study examined the biomass allocation strategies and lead (Pb) enrichment characteristics of various dwarf bamboo tissues by the end of the growing season and explored their potential for phytoremediation of Pb stress in the soils. Six dwarf bamboo genotypes were treated with three levels (0, 300, and 1500 mg kg) of soil Pb stress.

Different strategies for lead detoxification in dwarf bamboo tissues.

Dwarf bamboo Sasa argenteostriata (Regel) E.G. Camus is considered as potential plants for metal phytoremediation in previous filed observations.

A negative feedback regulatory loop between miR-138 and TP53 is mediated by USP10.

TP53 is a critical tumor suppressor. In approximately 50% of human cancers the TP53 gene is either lost or mutated. The expression level of TP53 in the cells is tightly controlled by a fine-tune machinery, mainly through the Mdm2-mediated ubiquitination pathway.

EDTA-facilitated toxic tolerance, absorption and translocation and phytoremediation of lead by dwarf bamboos.

Bamboos are considered as potential plants for phytoremediation. However, the mechanisms of EDTA-assisted bamboo for lead (Pb) control has not been described. The objective of this study was to examine the tolerance and behaviors of Pb to screen bamboos for Pb-contaminated soil and to explore the effects of EDTA on their phytoremediation.

Friend or Foe: MicroRNAs in the p53 network.

The critical tumor suppressor gene TP53 is either lost or mutated in more than half of human cancers. As an important transcriptional regulator, p53 modulates the expression of many microRNAs. While wild-type p53 uses microRNAs to suppress cancer development, microRNAs that are activated by gain-of-function mutant p53 confer oncogenic properties.

miR-130a Deregulates PTEN and Stimulates Tumor Growth.

H-RasV12 oncogene has been shown to promote autophagic cell death. Here, we provide evidence of a contextual role for H-RasV12 in cell death that is varied by its effects on miR-130a. In E1A-immortalized murine embryo fibroblasts, acute expression of H-RasV12 promoted apoptosis, but not autophagic cell death.

RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21.

Targeted inhibition of oncogenic miRNA-21 has been proposed to treat glioblastoma by rescuing tumor suppressors, PTEN and PDCD4. However, systemic delivery of anti-miR-21 sequences requires a robust and efficient delivery platform to successfully inhibit this druggable target. Three-way-junction (3WJ)-based RNA nanoparticles (RNP), artificially derived from pRNA of bacteriophage phi29 DNA packaging motor, was recently shown to target glioblastoma.

ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5.

MicroRNAs (miRNA) are mostly downregulated in cancer. However, the mechanism underlying this phenomenon and the precise consequence in tumorigenesis remain obscure. Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497.

MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer.

Lung cancer is the leading cause of cancer-related deaths worldwide. Despite advancements and improvements in surgical and medical treatments, the survival rate of lung cancer patients remains frustratingly poor. Local control for early-stage nonsmall cell lung cancer (NSCLC) has dramatically improved over the last decades for both operable and inoperable patients.

Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5.

The mechanism by which the 8q24 MYC enhancer region, including cancer-associated variant rs6983267, increases cancer risk is unknown due to the lack of protein-coding genes at 8q24.21. Here we report the identification of long noncoding RNAs named cancer-associated region long noncoding RNAs (CARLos) in the 8q24 region.

Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer.

MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a cohort of stage 1 nonsmall cell lung cancers (n = 81) and determined that miR-486 was the most down-regulated miRNA in tumors compared with adjacent uninvolved lung tissues, suggesting that miR-486 loss may be important in lung cancer development.