Matrine reduces the secretion of exosomal circSLC7A6 from cancer-associated fibroblast to inhibit tumorigenesis of colorectal cancer by regulating CXCR5.

Tumor microenvironment (e.g., stromal cells) has been suggested to be implicated in colorectal cancer (CRC) progression.

Laparoscopic diagnosis and extraction of an ingested fish bone that penetrated the stomach: A case report.

Rationale: Foreign body ingestion is a common clinical event, but serious complication such as perforation is uncommon. Here we present a case of gastrointestinal perforation caused by fish bone, which was treated effectively and successfully by totally laparoscopic management.

Patient Concerns: A 63-year-old man who was admitted to our hospital with epigastric pain for 1 month.