Publications by authors named "Zhengfeng Xuan"
Primary liver cancer (PLC) is a primary cause of cancer-related death worldwide, and novel treatments are needed due to the limited options available for treatment and tumor heterogeneity. 66 surgically removed PLC samples were cultured using the self-developed 2:2 method, and the final success rate for organoid culture was 40.9%.
View Article and Find Full Text PDFBackground & Aims: XBP1, most conserved transcription factor of endoplasmic reticulum stress, plays important roles in physiological and pathologic settings and has profound effects on disease progression and prognosis, so it is necessary to investigate XBP1 in macrophage-originated sterile inflammation during liver ischemia/reperfusion injury (IRI). Macrophage XBP1 expression and liver injury are analyzed in patients undergoing ischemia-related hepatectomy.
Methods: A myeloid-specific male XBP1-knockout (XBP1) strain is created for function and mechanism of XBP1 on macrophage-derived sterile inflammation in murine liver IRI with in vitro parallel research.
Article Synopsis
- Hepatocellular carcinoma (HCC) presents a challenge for effective treatment due to limited long-term benefits from immune checkpoint blockade therapy, necessitating a better understanding of immunotherapy resistance mechanisms.
- The study compiled 220 samples using single-cell RNA sequencing to explore the tumor microenvironment, focusing on cancer-associated fibroblast (CAF) subsets and their effects on immune responses in HCC patients.
- Findings reveal that POSTN CAFs act as barriers to T-cell infiltration and increase immunotherapy resistance by interacting with SPP1 macrophages, suggesting that targeting these specific CAF populations could enhance treatment outcomes.