DSCAM-AS1 accelerates cell proliferation and migration in osteosarcoma through miR-186-5p/GPRC5A signaling.

Osteosarcoma (OS) is one of the most primary bone malignancies, often occurring in adolescents or children. Numerous scientific findings have introduced that long noncoding RNAs (lncRNAs) can be involved in tumor occurrence and development. Although DSCAM-AS1 has been studied in several cancers, its role and mechanism in OS are poorly understood.

Efficacy of sertraline for post-stroke depression: A systematic review protocol of randomized controlled trial.

Background: Depression is a prevalent disorder for patients with stroke. Clinical researches indicate that sertraline is utilized to treat post-stroke depression (PSD) effectively. However, no systematic review has investigated this issue yet presently.

Percutaneous Electrical Nerve Stimulation for Chronic Knee Pain: A Randomized, Sham-controlled Trial.

Context: Anti-inflammatory drugs are often used to treat chronic knee pain (CKP), but their long-term use is associated with decreased effectiveness and numerous side effects. Complementary and alternative medicine provides additional treatments for the condition, including percutaneous electrical nerve stimulation (PENS). However, the benefits of PENS for treatment of CKP are still controversial.

The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells.

Sulfur dioxide (SO2) is a common air pollutant and can cause harmful insults on neurons. Microglial activation has been implicated in the signaling cascades that contribute to neuronal cell death in various neurological disorders. In the present study, we found that SO2 derivatives decreased cell viability via inducing oxidative stress, inflammatory responses and apoptotic cell death in BV2 microglial cells.