Publications by authors named "Zhengda Li"

Energy metabolism homeostasis is essential for oocyte maturation and acquisition of developmental capacity. However, bovine oocyte in vitro maturation (IVM) is highly susceptible to metabolic stress and lipid accumulation. β-Aminoisobutyric acid (BAIBA), a metabolite produced in response to skeletal muscle exercise, has been reported to be involved in lipid and glucose metabolism, as well as inflammation and oxidative stress.

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Article Synopsis
  • - Quantum networks facilitate secure communication by enabling tasks like Quantum Conference Key Agreement (QCKA), which allows multiple users to share secure keys.
  • - Traditional QCKA struggles with long-distance key distribution due to the delicate nature of Greenberger-Horne-Zeilinger (GHZ) states, but Measurement-Device-Independent QCKA (MDI-QCKA) offers a solution by improving security and reducing loopholes.
  • - Recent advancements in three-photon GHZ interference technology led to a successful MDI-QCKA experiment over 60 km, achieving a secret key rate of 45.5 bits/s and marking progress towards practical long-distance quantum communications.
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In response to the suboptimal electrochemical performance of low-valence vanadium oxides, Ganoderma lucidum biomass-derived carbon@VO (VO@CGL) composites were prepared by evaporative self-assembly technology and high-temperature calcination. In the prepared composites, VO effectively encapsulates CGL, serving as a support for VO and enhancing electrical conductivity and structural stability. This results in improved overall performance for the composites.

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Quantum networks promise unprecedented advantages in information processing and open up intriguing new opportunities in fundamental research, where network topology and network nonlocality fundamentally underlie these applications. Hence, the detections of network topology and nonlocality are crucial, which, however, remain an open problem. Here, we conceive and experimentally demonstrate to determine the network topology and network nonlocality hosted by a triangle quantum network comprising three parties, within and beyond Bell theorem, with a general witness operator for the first time.

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Non-Hermitian systems can exhibit unique quantum phases without any Hermitian counterparts. For example, the latest theoretical studies predict a new surprising phenomenon that bulk bands can localize and dissipate prominently at the system boundary, which is dubbed the non-Hermitian edge burst effect. Here we realize a one-dimensional non-Hermitian Su-Schrieffer-Heeger lattice with bulk translation symmetry implemented with a photonic quantum walk.

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The Hippo signalling pathway is a conserved kinase cascade that orchestrates diverse cellular processes, such as proliferation, apoptosis, lineage commitment and stemness. With the onset of society ages, research on skeletal aging-mechanics-bone homeostasis has exploded. In recent years, aging and mechanical force in the skeletal system have gained groundbreaking research progress.

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Zinc, an essential trace mineral, exerts a pivotal influence in various biological processes. Through zinc concentration analysis, we found that the zinc concentration in the bovine embryo in vitro culture (IVC) medium was significantly lower than that in bovine follicular fluid. Therefore, this study explored the impact of zinc sulfate on IVC bovine embryo development and investigated the underlying mechanism.

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Egg weight (EW) and age at first egg (AFE) are economically important traits in breeder chicken production. The genetic basis of these traits, however, is far from understood, especially for broiler breeders. In this study, genetic parameter estimation, genome-wide association analysis, meta-analysis, and selective sweep analysis were carried out to identify genetic loci associated with EW and AFE in 6,842 broiler breeders.

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Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, and health. Traditionally, endocrinologists have focused on one hormone or organ system at a time. Yet, hormone signaling by its very nature connects cells of different organs and involves crosstalk of different hormones.

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Studies of quantitative systems and synthetic biology have extensively utilized models to interpret data, make predictions, and guide experimental designs. However, models often simplify complex biological systems and lack experimentally validated parameters, making their reliability in perturbed systems unclear. Here, we developed a droplet-based synthetic cell system to continuously tune parameters at the single-cell level in multiple dimensions with full dynamic ranges, providing an experimental framework for global parameter space scans.

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Introduction: Attempts to artificially activate unfertilized oocytes at 24 h post intracytoplasmic sperm injection (ICSI) have generally resulted in poor outcomes. This study aims to explore a new strategy for early judgement and rescue activation of unfertilized oocytes at 5 h post ICSI to avoid unexpected fertilization failure (UFF) or unexpected low fertilization (ULF) in ICSI cycles.

Methods: Firstly, time-lapse data from 278 ICSI cycles were retrospectively analyzed to establish an indicator for fertilization failure prediction.

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In vitro maturation (IVM) methods for porcine oocytes are still deficient in achieving full developmental capacity, as the currently available oocyte in vitro culture systems still have limitations. In vitro embryo production must also improve the porcine oocyte IVM system to acquire oocytes with good developmental potential. Herein, we tested a three-dimensional (3D) glass scaffold culture system for porcine oocyte maturation.

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Heisenberg-type measurement uncertainty relations (MURs) of two quantum observables are essential for contemporary research in quantum foundations and quantum information science. Going beyond, here we report the first experimental study of MUR of three quantum observables. We establish rigorously MURs for triplets of unbiased qubit observables as combined approximation errors lower bounded by an incompatibility measure, inspired by the proposal of Busch et al.

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Background: Does short-interval second ejaculation improve sperm quality, embryo development and clinical outcomes for oligoasthenozoospermia males received intracytoplasmic sperm injection (ICSI) treatment?

Methods: All enrolled male patients underwent short-interval secondary ejaculation on the day of oocyte retrieval, and 786 sibling MII oocytes from 67 cycles were equally divided into two groups based on whether the injected spermatozoons originated from the first or second ejaculation. Semen parameters, embryo development efficiency, morphokinetic parameters and clinical outcomes were compared between the two groups to assess the efficiency and clinical value of short-interval second ejaculation in ICSI cycles.

Results: Short-interval second ejaculation significantly improved sperm motility, normal morphological rate, and sperm DNA integrity both before and after sperm swim-up.

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In inertial confinement fusion, high-precision x-ray imaging is crucial for understanding the states of matter under extreme conditions. To observe the target asymmetry during compression, multiple imaging spots with varying energy responses are necessary. However, integrating multiple imaging channels in a grazing incidence x-ray imaging scheme is challenging, and there is an urgent need for effective combination of multi-color and high-throughput diagnostics.

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Article Synopsis
  • CBX4 is part of the Polycomb group proteins involved in various biological processes, but its deletion can have contrasting effects depending on the tissue type and disease context.
  • This study shows that deleting CBX4 in lung adenocarcinoma (LUAD) with Kras mutations accelerates cancer cell growth and progression, with significant apoptosis occurring in the initial stages of cell transformation.
  • Analysis revealed that CBX4 deletion leads to genomic instability and changes in key cellular pathways, linking low CBX4 expression to poorer patient outcomes in LUAD, highlighting its potential as a therapeutic target.
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The weight of breast muscle (WBM) is a highly monitored indicator in broiler breeding that can be obtained after slaughtering. Currently, due to the lack of accurate in vivo phenotypes for both genomic and phenotypic selection, genetic gains in WBM fall short of initial expectations. In this study, 1,006 market-age (42 d) broilers from 3 generations over 2 yr were randomly selected, and the breast width (BW), fossil bone length (FBL), breast muscle thickness (BMT), and live weight (LW) were measured exactly in vivo.

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Follicular atresia is a normal physiological event in mammals, yet its mechanism remains to be studied. Granulosa cell (GC) autophagy is closely associated with follicular atresia. The N6-methyladenosine (m6A) modification is the most common post-transcriptional modification in eukaryotes, but its role in follicular atresia is still unknown.

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Introduction: Nondestructive detection of crop phenotypic traits in the field is very important for crop breeding. Ground-based mobile platforms equipped with sensors can efficiently and accurately obtain crop phenotypic traits. In this study, we propose a dynamic 3D data acquisition method in the field suitable for various crops by using a consumer-grade RGB-D camera installed on a ground-based movable platform, which can collect RGB images as well as depth images of crop canopy sequences dynamically.

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Aim: The purpose of this study was to investigate the effect of esmolol (ES) on LPS-induced cardiac injury and the possible mechanism. Methods: Sepsis was induced by i.p.

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In this article, we reported on a GaO-based Schottky barrier diode and heterojunction diode from MOCVD. The Si-doped n-type GaO drift layer, grown by MOCVD, exhibited high crystal quality, flat surfaces, and uniform doping. The distribution of unintentional impurities in the films was studied.

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While Bell nonlocality of a bipartite system is counterintuitive, multipartite nonlocality in our many-body world turns out to be even more so. Recent theoretical study reveals in a theory-agnostic manner that genuine multipartite nonlocal correlations cannot be explained by any causal theory involving fewer-partite nonclassical resources and global shared randomness. Here, we provide a Bell-type inequality as a test for genuine multipartite nonlocality in network by exploiting a matrix representation of the causal structure of a multipartite system.

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The lobster eye telescope is promising for large-field x ray imaging in astronomy. The special structure of the lobster eye system makes the focal plane a sphere, resulting in detector defocus when the field is large. In this study, we established a model based on the principle of lobster eye imaging and simulated the imaging at different image distances.

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Xist plays a critical role in the X-chromosome inactivation (XCI), an important epigenetic reprogramming of somatic cell nuclear transfer (SCNT) embryos. Modulation of Xist expression enhanced the developmental ability of mouse cloned embryos. However, the roles of Xist in buffalo SCNT embryos remain unknown.

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