Publications by authors named "Zhengchun Zhu"
Background: Centromere protein N (CENPN), located on chromosome 16q23.2, encodes vital nucleosome-associated complexes that are essential for dynamic assembly processes. CENPN plays a pivotal role in regulating cell proliferation and cell cycle progression by influencing mitotic events.
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- Duodenal adenocarcinoma (DAC) is a rare cancer that often spreads to the liver, and this study aimed to investigate how various factors affect survival rates in these patients.* -
- An analysis of 482 DAC patients from the SEER database revealed low overall (25.4%) and cancer-specific survival rates (28.3%) at one year, with significant correlations found for chemotherapy and surgery improving survival, while radiotherapy had no benefits.* -
- The findings suggest that chemotherapy and surgical intervention can enhance survival outcomes for DAC patients with liver metastasis, guiding future treatment strategies.*
Duodenal adenocarcinoma is an uncommon, malignant tumor usually accompanied by a poor prognosis. We identified 3150 duodenal adenocarcinoma cases from the SEER database (1988-2013) to analyze clinical characteristics and outcomes. The Kaplan-Meier method was used to evaluate cancer-specific survival (CSS).
View Article and Find Full Text PDFCancer Chemoradiotherapy Duo: Nano-Enabled Targeting of DNA Lesion Formation and DNA Damage Response.
ACS Appl Mater Interfaces
October 2018
Both production of DNA damage and subsequent prevention of its repair are crucial in concluding the therapeutic outcome of radiotherapy (RT). However, nearly all current strategies for improving RT focus only on one of the two aspects and overlook the necessity of their combinations. In this work, we introduce a concept of DNA-dual-targeting nanomedicine (NM) to simultaneously enhance DNA lesion formation and prevent the succeeding repair.
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