Extract Protects Glutamate-Induced Nerve Cell Damage by Inhibiting Receptor Activation.

Neurocytotoxicity elicited by receptors (NMDAR) is a substantial contributor to neurodegenerative diseases. Our current study expands on the previous findings in which (L.) extract (PAS840) was shown to protect PC12 cells from hydrogen peroxide-induced injury.

Investigation of the effects of (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota.

Ischemic stroke (IS) is a highly lethal type of cardiovascular and cerebrovascular disease. Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut-brain axis as a therapeutic target. In this study, we evaluated the regulatory effect of (L.

Water-soluble polysaccharides from finger citron fruits (Citrus medica L. var. sarcodactylis).

Four water-soluble polysaccharides, FCp-1, FCp-2, FCp-3, and FCp-4 were obtained from finger citron fruits (Citrus medica L. var. sarcodactylis) by hot-water extraction and ethanol precipitation, followed by routine separation procedure.

An arabinogalactan from flowers of Chrysanthemum morifolium: structural and bioactivity studies.

A water-soluble polysaccharide (P2) with a molecular weight of 1.7×10(5)Da was isolated from the hot aqueous extract of flowers of the Chrysanthemum morifolium. It was homogeneous for there was only a symmetrical peak on the spectrum of high-performance gel permeation chromatography.

Cytotoxic triterpenoids from Lysimachia parvifolia.

Five new oleanane-type triterpenoids, including two aglycones, 13β-28-epoxy-3β,22α,23-trihydroxyolean-16-one (1) and 13β-28-epoxy-22α,23-dihydroxyolean-3,16-dione (2), and three glycosides, anagalligenone-3-O-α-L-arabinopyranoside (3), anagalligenone-3-O-[β-D-glucopyranosyl(1 → 4)-α-L-arabinopyranoside] (4) and anagalligenone-3-O-[β-D-xylopyranosyl(1 → 2)-β-D-glucopyranosyl(1 → 4)-α-L-arabinopyranoside] (5), were isolated from the aerial parts of Lysimachia parvifolia, together with three known oleanane-type triterpenoid glycosides (6-8). The structures of the new compounds were subsequently elucidated by spectroscopic analysis and their cytotoxicities evaluated against six human cancer cell lines. Compounds 5-8 exhibited significant cytotoxicities against all the cell lines tested, with IC50 values lower than 10 μM.

[Detection of bcl-2/IgH fusion gene in lymphoma by real-time polymerase chain reaction and its clinical significance].

The aim of this study was to investigate the bcl-2/IgH expression levels in patients with follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) and its clinical significance. The bcl-2/IgH expression levels in bone marrow (BM) and/or peripheral blood (PB) of 20 patients were detected by using SYBR Green I real-time polymerase chain reaction, and the dynamic monitoring for bcl-2/IgH expression level in 4 of these patients was performed. The results showed that in patients with bcl-2/IgH-positive there was no statistically significant difference in the relative copy-numbers of bcl-2/IgH fusion gene in BM and PB (4.

[Review on investigations related to chemical constituents and biological activities of Periplaneta americana].

With the fast development of medicinal animals as new drugs, research on Periplaneta americana become hot recently. Several drugs which mainly consisted of P. americana were approved for clinical applications.