Publications by authors named "Zhengchuang Fu"

Article Synopsis
  • Patients with schizophrenia experience heightened inflammation during acute episodes, and the neutrophil/lymphocyte ratio (NLR) could serve as a potential biomarker for these exacerbations.
  • A study involving 651 participants (including both healthy controls and various patient groups) analyzed inflammatory indices and found that NLR was significantly higher in drug-free and medicated patients during acute phases compared to healthy individuals.
  • While NLR correlated with disease duration and mood stabilizer use, the platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) showed no significant differences among the patient groups or with healthy controls.
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Background: Inflammation is crucial in the development of depression. This study aims to examine the potential association between the Neutrophil-Percentage-to-Albumin Ratio(NPAR) and depression symptoms.

Methods: This study adopted a cross-sectional design, involving patients with depression symptoms and those without depression symptoms with comprehensive NPAR data originated from the National Health and Nutrition Examination Survey(NHANES) spanning 2011 to 2018.

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Many studies have investigated the changes of immune cells and proinflammatory cytokines in patients with acute schizophrenia, but few studies have investigated the functional phenotypes of immune cells and the expression rate of programmed cell death protein 1 (PD-1)/ programmed cell death-Ligand 1 (PD-L1). The aim of this study was to investigate the extent of immune cells activation, PD-1/PD-L1 expressions, and altered cytokine levels in drug-naïve schizophrenia patients with acute-phase. 23 drug-naïve schizophrenia patients in acute-phase and 23 healthy individuals were enrolled in this study as experimental and control groups, separately.

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Background: Few studies have investigated the relative factors of thyroid dysfunction in major depressive disorder (MDD) patients with Metabolic syndrome (MetS). This study aimed to explore the prevalence and related factors associated with thyroid dysfunction in drug-naïve (FEDN) MDD patients with MetS.

Methods: 1718 FEDN MDD patients were recruited and their demographic data, clinical data were collected.

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Comorbid glucose metabolism abnormalities are very common in patients with major depressive disorder (MDD), and glucose metabolism and lipid metabolism are closely related. However, there are few researches on the incidence and related factors of lipid metabolism abnormalities among MDD patients with comorbid glucose metabolism abnormalities. A cross-sectional study involving 1718 first-episode and drug-naïve (FEDN) MDD patients was conducted.

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Background: Lipid metabolism is associated with glucose metabolism, but whether there are variations between sexes in risk factors and prevalence of abnormal lipid metabolism in major depressive disorder (MDD) patients with glucose metabolism abnormalities remains ambiguous. In the present study, the frequency and risk factors of dyslipidemia in first-episode and drug-naïve (FEDN) MDD patients with dysglycemia were examined according to sex.

Methods: One thousand seven hundred and eighteen FEDN MDD patients were recruited and their demographic data, clinical data, various biochemical indicators and scale assessment scores including 17-item Hamilton Rating Scale for Depression (HAMD-17), 14-item Hamilton Anxiety Rating Scale (HAMA-14), and positive subscale of the Positive and Negative Syndrome Scale (PANSS) were collected.

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