Publications by authors named "Zhengchang Wen"
Article Synopsis
- Duck enteritis virus (DEV) causes significant damage to ducks, affecting their vascular and gastrointestinal systems, while Poly I:C shows potential as an antiviral treatment by boosting interferon levels.
- This study aimed to analyze how DEV leads to intestinal injury and to assess the effectiveness of different doses of Poly I:C in treating this condition in infected ducks.
- Results indicated that Poly I:C significantly improved intestinal health and reduced cell death caused by DEV, with higher doses providing even better protection, suggesting its potential for future antiviral drug development.
Duck viral enteritis (DVE) is a lethal viral disease caused by duck enteritis virus (DEV) via an unknown mechanism. This study explores the relationship between Chinese standard challenge strain DEV (DEV-CSC)-induced apoptosis and endoplasmic reticulum stress (ERS) in duck embryo fibroblast (DEF) cells. Here we examined changes in Ca concentration, cell proliferation, apoptosis, and the differential expression of C/EBP homologous protein (CHOP), glucose regulatory protein 78 (GRP78), and activating transcription factor 6 (ATF6) in infected cells.
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