Identifying CpG methylation signature as a promising biomarker for recurrence and immunotherapy in non-small-cell lung carcinoma.

Epigenetic alterations are crucial to oncogenesis and regulation of gene expression in non-small-cell lung carcinoma (NSCLC). DNA methylation (DNAm) biomarkers may provide molecular-level prediction of relapse risk in cancer. Identification of optimal treatment is warranted for improving clinical management of NSCLC patients.

Chirality switching of the self-assembled CuPc domains induced by electric field.

Chiral switching of the self-assembled domains of CuPc molecules on the Cd(0001) surface has been investigated by means of a low temperature scanning tunneling microscopy (STM). With the coverage increasing, the CuPc molecules show the structural evolutions from an initial gas-like state to a network phase, a square phase, and finally to a compact phase at full monolayer. In the network and square phases, the achiral CuPc molecules reveal both the point chirality and chiral domains.