Publications by authors named "Zhengbing Xiang"
Background: To assess the clinical and safety outcomes of endovascular treatment (EVT) administered more than 24 h after the onset of symptoms in patients with acute ischemic stroke resulting from anterior circulation large-vessel occlusion or stenosis (AIS-ACLVO/S).
Methods: We enrolled consecutive AIS-ACLVO/S patients who received EVT in our hospital between January 2019 and February 2022 and divided them into two groups based on the time from AIS onset to EVT: EVT < 24 h group and EVT >24 h group. The successful reperfusion (modified thrombolysis in cerebral infarction, [mTICI] ≥2b), 90-day modified Rankin Scale score (mRS), intracranial hemorrhage (ICH), and symptomatic ICH (sICH), as well as mortality, were analyzed in the two groups of patients.
Objective: The utility of metagenomic next-generation sequencing (mNGS) in the diagnosis of tuberculous meningitis (TBM) remains uncertain. We performed a meta-analysis to comprehensively evaluate its diagnostic accuracy for the early diagnosis of TBM.
Methods: English (PubMed, Medline, Web of Science, Cochrane Library, and Embase) and Chinese (CNKI, Wanfang, and CBM) databases were searched for relevant studies assessing the diagnostic accuracy of mNGS for TBM.
Article Synopsis
- Tuberculous meningitis (TBM) is the leading form of central nervous system tuberculosis, associated with high rates of mortality and disability, making early diagnosis crucial for improving patient outcomes.
- The traditional diagnostic methods for TBM, which include microscopy, culture, and PCR, are often ineffective due to the low bacterial load in the cerebrospinal fluid (CSF) and the limitations of conventional techniques.
- This review highlights the current landscape of TBM diagnostics, emphasizing ongoing research, the pros and cons of available methods, and the challenges clinicians face in ensuring accurate and efficient diagnosis.
Article Synopsis
- The study focuses on tuberculous meningitis (TBM) in South China, particularly looking at the occurrence of cranial nerve palsy as a serious complication in these patients.
- Out of 114 patients analyzed, about 33.3% experienced cranial nerve palsy, with the most common types being oculomotor and optic nerve palsies.
- Key risk factors identified for developing cranial nerve palsy included the presence of focal neurological deficits, extracranial tuberculosis, and elevated total white cell count in cerebrospinal fluid.
Exploration of the Risk Factors of Anemia in Patients with Tuberculous Meningitis in South China.
Neuropsychiatr Dis Treat
February 2023
Objective: Central nervous system (CNS) infection has a high incidence and mortality worldwide. Tuberculous meningitis (TBM) accounts for approximately 5-6% of all extrapulmonary tuberculosis (TB), and is considered an extremely lethal form of CNS TB, which has become an important threat to human health. Anemia is a common symptom of TB, and its prevalence is generally higher in patients with TBM than in other meningitis patients and healthy individuals.
View Article and Find Full Text PDFPurpose: The aim of this study is to evaluate the safety and effectiveness of endovascular treatment (EVT) for acute ischemic stroke caused by large-vessel obstruction or stenosis (AIS-LVO/S) over 24 h after first AIS symptom recognition (FAISSR).
Methods: A total of 33 AIS-LVO/S cases with EVT over 24 h after FAISSR during the period from January 2019 to February 2022 in our hospital were divided into the 90d mRS ≤ 2 group [favorable outcome (FO) group] and 90d mRS > 2 group [unfavorable outcome (UFO) group] and retrospectively analyzed.
Results: The reperfusion was successfully established with EVT in 97% (32/33) of cases, and most (63.
Background: Tuberculous meningitis (TBM) is the most serious form of extrapulmonary tuberculosis caused by , and is characterized by high morbidity and mortality. Unfortunately, it is difficult to distinguish TBM from bacterial meningitis (BM) based on clinical features alone. The latest diagnostic tests and neuroimaging methods are still not available in many developing countries.
View Article and Find Full Text PDFObjective: This study aimed to explore the mechanism of Nobiletin attenuating Alzheimer's disease (AD) by inhibiting neuroinflammation.
Methods: The expression of inflammatory cytokines and HMGB-1 in serum of AD patients were examined. Microglia (MGs) were treated with different doses of Nobiletin before LPS and Nigericin induction.
Objective: To investigate the protective effect of MZF1/RBM3 on rotenone-induced neuronal injury.
Methods: Rotenone (1 μM) was used to treat SH-SY5Y cells for 24 hr to simulate the cellular model of Parkinson's disease (PD), followed by detection of SH-SY5Y cell activities using MTT assay. MZF1 expression in rotenone-treated SH-SY5Y cells was detected by qRT-PCR and Western blot.
Article Synopsis
- There is growing evidence that suggests inflammatory bowel disease (IBD) and Parkinson's disease (PD) share similar pathological mechanisms, but they differ in their epidemiological features.
- A systematic review analyzed nine observational studies involving over 12 million patients and found a significant increased risk of PD in individuals with IBD, with an adjusted risk ratio of 1.24.
- Findings indicated that the incidence of IBD increased both before and after a PD diagnosis, particularly highlighting that older IBD patients and those not treated with specific therapies had a notably higher risk of developing PD.
To determine whether glycated hemoglobin and mean arterial pressure (MAP) during thrombolysis are prognostic factors of intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) for acute ischemic stroke (AIS).A total of 125 AIS patients, who received rt-PA intravenous thrombolysis in our hospital, were included into the present study, and divided into good prognosis group and poor prognosis group. Univariate and multivariate logistic regression analyses were used to determine the prognostic factors of AIS treated by rt-PA thrombolysis, Spearman correlation analysis was used to analyze the correlation of the accumulated cigarette consumption in the smoking subgroup and glycated hemoglobin in the diabetic subgroup with the prognosis after intravenous thrombolysis and the symptomatic intracranial hemorrhage (sICH).
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